transcriptomics – Page 11

Transcriptomic Profiling of Thermotolerant Sarcomyxa edulis PQ650759 Reveals the Key Genes and Pathways During Fruiting Body Formation

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Researchers studied how a special strain of Sarcomyxa edulis (a tasty edible mushroom from Northeast China) develops fruiting bodies by analyzing which genes are turned on and off during this process. By comparing immature mycelium with developing fruiting bodies, they identified key genes responsible for cell division, DNA repair, and energy metabolism that control fruiting body formation. This knowledge can help mushroom farmers improve yield and quality through better understanding of how mushrooms grow. The findings provide a foundation for developing better cultivation techniques and selecting superior mushroom strains for commercial production.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom species to understand how different growing methods affect its beneficial compounds. They found that growing the mushroom on specific wood substrates (from cinnamon trees) produced much higher levels of therapeutic compounds compared to rice-based cultivation. Using advanced molecular techniques, they identified the genes responsible for producing these medicinal compounds and how they are controlled, providing insights to improve mushroom cultivation for better health benefits.

Integrated Transcriptomic and Proteomic Analyses Reveal Molecular Mechanism of Response to Heat Shock in Morchella sextelata

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Morels are delicious edible mushrooms, but growing them is challenging when temperatures get too high. Scientists studied two morel strains to understand how they respond to heat stress by examining their genes and proteins. They found that heat-tolerant strains activate special protective proteins and metabolic pathways, with one strain particularly good at activating a protein called Rsp5 that helps other protective proteins work better. These findings could help farmers grow better morels even as climate change makes temperatures warmer.

Exploring the Critical Environmental Optima and Biotechnological Prospects of Fungal Fruiting Bodies

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This research identifies the ideal growing conditions for fungal fruiting bodies like mushrooms, showing that temperature around 25°C, high humidity, and proper light exposure are key factors. The study reveals that exceeding these optimal conditions typically harms development more than staying slightly below them. Scientists discovered that fungal fruiting bodies have important uses in medicine, food production, and environmental cleanup, and new genetic technologies like CRISPR could improve cultivation methods for better yields and quality.

Transcriptional programs mediating neuronal toxicity and altered glial–neuronal signaling in a Drosophila knock-in tauopathy model

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Researchers created a fruit fly model of frontotemporal dementia by editing the tau gene to match a human disease mutation. Using advanced genetic sequencing technology, they analyzed how this mutation affects brain cells, discovering that it disrupts communication between nerve cells and support cells called glia. The study reveals multiple pathways that could be targeted with future treatments to combat this devastating brain disease.

Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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Cacao farmers have struggled to control witches’ broom disease, a fungal infection caused by Moniliophthora perniciosa, because the fungus survives even high doses of strobilurin fungicides. This study reveals how the fungus adapts to the fungicide by switching its metabolism to use alternative energy sources, activating detoxification systems, and using an alternative respiratory pathway. Researchers also discovered that prolonged fungicide exposure can create even more resistant mutants with mutations in genes that control fungal growth and gene expression.

Integrated Transcriptomic and Proteomic Analyses Reveal Molecular Mechanism of Response to Heat Shock in Morchella sextelata

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Morels are delicious mushrooms that are difficult to grow because they are very sensitive to high temperatures. Scientists compared two different morel strains to understand why one variety can tolerate heat better than the other. By studying the genes and proteins expressed at normal and high temperatures, researchers discovered that the heat-tolerant strain activates specific protective mechanisms, particularly through a protein called Rsp5 that helps boost other protective proteins. This research provides valuable information for breeding morel varieties that can survive warmer growing conditions in the age of climate change.

Effects of a biotechnologically produced Pleurotus sapidus mycelium on gut microbiome, liver transcriptome and plasma metabolome of broilers

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Researchers tested whether mushroom mycelium grown using agricultural waste could be safely added to chicken feed. The mycelium, rich in beneficial compounds like β-glucans, was added to broiler diets at varying levels for 35 days. Results showed that chickens fed diets containing up to 5% mushroom mycelium performed just as well as control chickens, with no negative effects on health, digestion, or metabolism, suggesting this sustainable feed ingredient could help reduce competition between animal feed and human food.

Ex Vivo Host Transcriptomics During Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans Infection of Peripheral Blood Mononuclear Cells From South African Volunteers

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Researchers studied how human immune cells respond to three different fungal infections that commonly affect people with weakened immune systems. By examining gene activity in blood cells exposed to these fungi, they discovered that each fungus triggers different immune responses, with Candida albicans causing a much stronger reaction than the two Cryptococcus species. Only one shared immune pathway was activated by all three fungi, suggesting each infection requires different immune mechanisms to fight off. These findings could help develop new treatments for serious fungal infections.

Multi-Omics Analysis of Low-Temperature Fruiting Highlights the Promising Cultivation Application of the Nutrients Accumulation in Hypsizygus marmoreus

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Scientists studied how beech mushrooms develop during a special low-temperature fruiting process that requires a long waiting period. They discovered that amino acids (particularly arginine) and citric acid accumulate during this process, and that adding these compounds externally can speed up mushroom production by 10 days and increase yield by 10-15%. This research could help mushroom farmers reduce costs and time in cultivation.

Research Keyword: transcriptomics