transcriptomics – Page 10

Inhibitory Effect and Mechanism of Dryocrassin ABBA Against Fusarium oxysporum

mycolabadmin

Researchers found that dryocrassin ABBA, a compound from a traditional East Asian fern, can effectively kill the fungus that causes potato rot disease. The compound damages the fungus by increasing harmful reactive oxygen species and disrupting the fungus’s ability to break down plant cell walls. This natural substance could potentially replace synthetic chemical fungicides, offering a safer and more environmentally friendly way to protect potatoes from disease.

Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis

mycolabadmin

Researchers identified how carabrone, a natural compound from plants, kills a fungus that causes wheat disease. The compound works by blocking a key energy-producing system (complex I) inside the fungus’s cells, which prevents it from producing enough energy to survive. This discovery is important because many current fungicides are losing effectiveness due to resistance, and this compound offers a new way to attack fungi. The findings could help develop new and more effective fungicides for protecting crops.

Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens

mycolabadmin

Researchers discovered that hydrogen sulphide (H2S), a small gas molecule, can effectively kill the fungi and bacteria that cause painful nail infections. Unlike current treatments that struggle to penetrate into the nail, hydrogen sulphide easily diffuses through the nail plate. The study found that H2S works by damaging the fungi’s respiratory system and creating harmful reactive oxygen species, while also modifying proteins in a way that disrupts their normal function. This innovative approach could offer patients a new topical treatment option for nail infections that have been difficult to treat with existing medications.

Transcriptomic and metabolomic analyses unravel the different pathogenic mechanisms of Ustilaginoidea virens in indica and japonica rice

mycolabadmin

Rice is vulnerable to a fungal disease called false smut caused by Ustilaginoidea virens. Scientists found that this fungus attacks different rice varieties in different ways. By studying gene expression and chemical changes in infected rice, they discovered that the fungus uses different molecular pathways to infect indica rice versus japonica rice, explaining why these varieties have different levels of resistance to the disease.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

mycolabadmin

Scientists studied how a special fungal treatment can boost the production of beneficial compounds in sanghuang mushrooms. Using advanced molecular analysis techniques, they found that the fungal elicitor significantly increased levels of healing compounds called triterpenes. The treated mushrooms produced 114 times more of one specific compound compared to untreated mushrooms. This research shows how we can grow medicinal mushrooms with higher levels of beneficial substances, which could help develop better treatments for various diseases.

Citric acid impairs type B trichothecene biosynthesis of Fusarium graminearum but enhances its growth and pigment biosynthesis: transcriptomic and proteomic analyses

mycolabadmin

Citric acid, a compound found in plant roots, has an interesting dual effect on a dangerous fungus called Fusarium graminearum that destroys grain crops worldwide. While citric acid helps the fungus grow better, it actually prevents the fungus from producing dangerous toxins called trichothecenes. This finding suggests that citric acid could potentially be used in farming to reduce the harmful toxins that contaminate wheat and corn while maintaining reasonable fungal control.

Integration of Metabolomes and Transcriptomes Provides Insights into Morphogenesis and Maturation in Morchella sextelata

mycolabadmin

Researchers studied how morel mushrooms develop from mycelium through fruiting body maturation by analyzing changes in their metabolites and genes across four growth stages. They found that the transition from vegetative growth to reproductive growth involves dramatic changes in carbohydrate, amino acid, and lipid metabolism, regulated by specific transcription factors. This understanding could help improve the cultivation of morels, which currently struggles with low fruiting rates despite their high value as food and medicine.

Transcriptome and metabolome profiling reveal the inhibitory effects of food preservatives on pathogenic fungi

mycolabadmin

This research tested three common food preservatives to see how well they stop harmful molds from growing on fruits and vegetables. Scientists found that all three preservatives worked well at different concentrations, with sec-butylamine being particularly effective. By studying the genes and chemical changes in treated fungal cells, they discovered that these preservatives work by damaging the mold’s cell walls and disrupting how it processes sugars, essentially starving and weakening the fungal cells.

Transcriptomic and metabolic profiling reveals adaptive mechanisms of Auricularia heimuer to temperature stress

mycolabadmin

Researchers studied how a popular edible mushroom called black wood ear (Auricularia heimuer) adapts to different temperatures. They found that the mushroom grows best at 35°C but struggles at very cold (15°C) or extremely hot (45°C) temperatures. By analyzing the genes and chemicals produced by the mushroom at different temperatures, scientists discovered that the mushroom uses different survival strategies depending on how hot or cold it is, which could help farmers grow better mushrooms.

Genetic regulation of l-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

mycolabadmin

Researchers studied how magic mushrooms (Psilocybe mexicana) control their chemical processes to make psilocybin. They found that when mushrooms start producing psilocybin, they turn on genes that make more of an amino acid called tryptophan, while turning off genes that would break it down. They also discovered and studied an enzyme that helps control tryptophan use. This understanding could help grow these mushrooms with more consistent psilocybin levels for legitimate medical research into treating depression.

Research Keyword: transcriptomics