Research Keyword: toxicity reduction

Pb immobilization by phosphate-solubilizing fungi and fluorapatite under different Mn2+ concentrations

Researchers studied how two types of beneficial fungi (Aspergillus niger and Penicillium chrysogenum) can remove dangerous lead contamination from environments. By adding the mineral fluorapatite and controlling the level of manganese in the growth medium, they found that Aspergillus niger was much more effective at capturing and permanently locking up lead particles, preventing them from leaching back into the environment. The optimal amount of manganese (7.5 mg/L) significantly boosted the fungi’s production of organic acids that capture lead, making this an environmentally friendly solution for cleaning polluted sites.

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Engineered biosynthesis and characterization of disaccharide-pimaricin

Scientists engineered a bacterium to produce a modified antibiotic called disaccharide-pimaricin that fights fungal infections with much better safety. This new compound dissolves better in water (107 times more soluble) and is much less toxic to human blood cells (12.6 times safer) compared to regular pimaricin, while still maintaining antifungal effectiveness. Through optimized fermentation processes, they achieved high production yields of 138 mg/L, making this a promising candidate for safer antifungal treatments.

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