Research Keyword: toenail infection

Efficacy of Topical Antifungal Nail Solution Versus Topical Placebo Solution for the Treatment of Pedal Onychomycosis: A Randomized Controlled Trial

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This study tested whether a new antifungal solution called Tolcylen® could effectively treat toenail fungus compared to a placebo. Over 9 months, participants using the active treatment showed dramatic improvements, with over half achieving complete fungal elimination and 70% showing significant nail healing. Beyond just getting rid of the fungus, patients reported much better quality of life with less discomfort and improved appearance as early as 3 months into treatment.

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Combination of Q-switched 1,064 and 532 nm Nd: YAG laser in the treatment of toenail onychomycosis: a pilot study

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This study tested a laser treatment using two different wavelengths (1,064 and 532 nanometers) to treat toenail fungal infections. Fifteen patients with toenail fungus received eight weekly laser sessions. The treatment was safe and worked best for mild cases, curing 100% of them, but was less effective for severe infections. Although patients experienced some pain during treatment, the overall results suggest laser therapy could be a useful option for treating mild fungal toenail infections without the side effects of oral medications.

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Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens

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Researchers discovered that hydrogen sulphide (H2S), a small gas molecule, can effectively kill the fungi and bacteria that cause painful nail infections. Unlike current treatments that struggle to penetrate into the nail, hydrogen sulphide easily diffuses through the nail plate. The study found that H2S works by damaging the fungi’s respiratory system and creating harmful reactive oxygen species, while also modifying proteins in a way that disrupts their normal function. This innovative approach could offer patients a new topical treatment option for nail infections that have been difficult to treat with existing medications.

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Addressing filamentous fungi-related onychomycosis in the era of antifungal resistance: assessment of Zataria multiflora nanostructured lipid carrier topical gel in a double-blinded clinical trial

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Nail fungal infections (onychomycosis) are difficult to treat, especially as fungi become resistant to standard antifungal medications. Researchers tested a new gel made from Zataria multiflora (Shirazi thyme) packaged in special nanoparticles that help the medicine penetrate the nail better. In a clinical trial comparing this gel to placebo, the Zataria multiflora treatment showed better results after just 2 weeks, with 70% of patients experiencing fungal cure compared to 55% with placebo.

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