Research Keyword: TLR4

β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment

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Researchers found that β-chitosan, a compound extracted from squid parietal bone, can reverse age-related memory and learning problems in mice, zebrafish, and worms. The compound works by reducing excessive inflammation in the liver and lowering inflammatory chemicals in the blood, which in turn reduces brain inflammation. This discovery suggests a direct connection between liver health and brain aging, and β-chitosan may offer a new therapeutic approach for age-related cognitive decline.

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Active Hexose-Correlated Compound Shows Direct and Indirect Effects against Chronic Lymphocytic Leukemia

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Researchers tested a mushroom-derived supplement called AHCC against chronic lymphocytic leukemia in laboratory and animal studies. AHCC killed leukemia cells directly and also reduced supportive cells in the tumor environment. When combined with antibody therapy, AHCC significantly improved outcomes in mouse models, suggesting it could be a promising addition to current leukemia treatments.

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Things you wanted to know about fungal extracellular vesicles (but were afraid to ask)

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Fungal extracellular vesicles are tiny particles released by fungal cells that play important roles in how fungi cause disease and how our immune system responds. These particles can either help fight infections or make them worse depending on the type of fungus and conditions involved. Scientists are discovering that these vesicles could potentially be used as vaccines and may explain why some antifungal drugs stop working.

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Three-phase extraction of polysaccharide from Stropharia rugosoannulata: Process optimization, structural characterization and bioactivities

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Researchers developed an efficient new method called three-phase extraction to isolate beneficial compounds called polysaccharides from wine cap mushrooms (Stropharia rugosoannulata). These polysaccharides showed strong antioxidant properties and boosted immune cell activity in laboratory tests by triggering specific cellular pathways. The findings suggest these mushroom extracts could become useful ingredients in functional foods or medicines to support immune health.

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Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review

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Coriolus versicolor, also known as turkey tail mushroom, has been used in traditional Chinese medicine for thousands of years. Recent scientific research shows it may help fight breast cancer through multiple mechanisms: killing cancer cells directly through programmed cell death pathways, breaking down the estrogen that fuels some breast cancers, preventing cancer spread, and boosting the immune system. While early studies are promising and one clinical trial showed good safety and immune benefits, larger studies are needed before this mushroom can be recommended as an official cancer treatment.

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