Research Keyword: tissue necrosis

Disseminated mucormycosis leading to a fatal gastrointestinal perforation in a pediatric case of EBV-associated Hemophagocytic lymphohistiocytosis

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A 12-month-old girl with a serious immune system disorder called HLH developed a rare and dangerous fungal infection called mucormycosis. Despite receiving the best available treatments, the fungal infection spread throughout her digestive system and caused a perforation (hole) in her intestines. The doctors found it difficult to diagnose the fungal infection early because the warning signs were subtle, and the infection progressed very rapidly. Unfortunately, the girl passed away despite emergency surgery and high-dose antifungal medications.

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Invasive Rhinocerebral Mucormycosis Is a Rare Complication in Systemic Juvenile Idiopathic Arthritis Patient

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A 5-year-old girl with systemic juvenile arthritis being treated with immunosuppressive medications developed a rare and serious fungal infection in her nose and sinuses caused by a mold called Lichtheimia. The infection caused tissue death and spread toward her brain, but was successfully treated with combination antifungal drugs and surgery. This case highlights how powerful immunosuppressive treatments for severe arthritis can increase the risk of life-threatening fungal infections.

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Clinical Challenges and Predictive Risk Factors for Outcomes in COVID-19–Associated Mucormycosis

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During the COVID-19 pandemic, a dangerous fungal infection called mucormycosis has become a serious complication, especially for patients with uncontrolled diabetes or those taking certain medications. Researchers studied 180 patients with this condition and found that the infection can spread from the sinuses to the eyes and brain, leading to severe outcomes. The most important factors in surviving this infection are early detection, keeping blood sugar controlled, careful use of steroids, and aggressive treatment with antifungal medications and sometimes surgery.

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