Research Keyword: tissue distribution

Efficacy of Rezafungin on Candida albicans Endophthalmitis in a Rabbit Model

Researchers tested a new antifungal drug called rezafungin against a serious eye infection caused by Candida fungus in rabbits. Rezafungin performed much better than two other commonly used antifungal drugs, completely eliminating the fungus from the eye while preventing infection-related damage. The drug’s ability to be given weekly instead of daily makes it more practical for treating patients with severe fungal eye infections.

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Efficacy of SCY-247, a Second-generation Triterpenoid Antifungal, in Three Murine Models of Invasive Fungal Infections

Researchers tested a new antifungal drug called SCY-247 in mice to treat serious fungal infections. The drug was given orally and showed strong effectiveness against common fungal infections caused by Candida and Rhizopus species, including strains resistant to current treatments. Higher doses of the drug produced better results, and the drug effectively concentrated in the organs most affected by fungal infections.

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