therapeutic efficacy – Page 2

Pharmacokinetics of Psilocybin: A Systematic Review

mycolabadmin

This review examines how the body processes psilocybin, a compound from magic mushrooms being studied for treating depression and anxiety. When taken orally, psilocybin is quickly converted to its active form, psilocin, which reaches peak levels in the bloodstream within 1-4 hours and is eliminated mainly through urine. The body’s ability to process psilocybin involves specific liver enzymes that vary between individuals, potentially explaining why people respond differently to the same dose and why certain medications can interfere with its effects.

Psychedelic-assisted psychotherapy: The need to monitor adverse events

mycolabadmin

While psychedelics show promise for treating depression and other mental health conditions, researchers need better systems to monitor and report any harmful effects they might cause. This paper calls for more careful, consistent tracking of both physical changes (like blood pressure) and psychological experiences during psychedelic therapy. The authors emphasize that safety monitoring should continue even after patients leave the clinic and that women may experience different side effects than men.

Attitudes toward psychedelics and psychedelic-assisted therapy among potential mental health service users and the general population in Australia

mycolabadmin

This Australian study surveyed over 500 people about their views on psychedelics like psilocybin and MDMA for treating mental health conditions. Most people supported medical legalization of these substances, though many had safety concerns. Those with mental illness, those with prior psychedelic experience, and those with better knowledge of psychedelics were most supportive of their therapeutic use.

Treating job-related stress with psychedelic group therapy: a case series on group ketamine-assisted psychotherapy for healthcare workers and first responders

mycolabadmin

Researchers tested a new group therapy approach using ketamine to help firefighters, police officers, paramedics, and healthcare workers dealing with job stress and burnout. Over seven weeks, 32 participants received three ketamine sessions combined with group therapy. The results showed significant improvements in anxiety, depression, trauma symptoms, and burnout within the group. This low-cost group approach not only helped individual symptoms but also created a supportive community where workers felt understood by others in similar situations.

Impact of Clove Oil on Biofilm Formation in Candida albicans and Its Effects on Mice with Candida Vaginitis

mycolabadmin

This research demonstrates that clove oil, a natural and FDA-approved dietary supplement, can effectively combat Candida albicans infections that cause vaginal yeast infections. The study found that clove oil works by preventing the fungus from forming protective biofilms and by reducing inflammation. In mice with vaginal yeast infections, clove oil treatment significantly improved symptoms and reduced fungal levels, suggesting it could serve as a safer alternative to conventional antifungal medications.

Efficacy assessments of SF001, a next-generation polyene antifungal, in a neutropenic mouse model of invasive fusariosis

mycolabadmin

This study tested a new antifungal drug called SF001 against a serious infection called fusariosis in mice. SF001 performed as well as the current standard treatment (amphotericin B) but with better safety profiles. The drug successfully reduced fungal infections in organs and improved survival rates in infected mice without showing signs of toxicity at higher doses.

Severe Outbreak of Saprolegnia Spp. Infection in Spotted Snakehead (Channa punctata, Bloch 1793): Clinical Assessment, Histopathology, Haemato-Biochemical Indices and Insights Into Therapeutic Effects

mycolabadmin

A severe fungal infection called saprolegniasis was found in 85% of spotted snakehead fish from Bangladesh, causing cotton-like growths, fin damage, and mass mortality. Researchers tested four different treatments over 10 days, finding that combining warm water (30°C) with saltwater (2% NaCl) was most effective, resulting in 70% survival compared to only 23% in untreated fish. This natural, cost-effective treatment approach could help fish farmers reduce losses from fungal diseases without relying on toxic chemicals.

A zinc-chelating cyclic alkyl polyamine compound is efficient and safe in a murine model of multidrug-resistant Candida auris infection

mycolabadmin

Researchers tested a new drug called APC6 that works by trapping zinc, which fungi need to survive. In mouse studies of a dangerous resistant fungus called Candida auris, APC6 saved all treated mice while most untreated mice died. The drug also reduced fungal infections in organs without causing serious side effects, suggesting it could become a new treatment option for serious fungal infections resistant to current medicines.

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

mycolabadmin

Scientists tested five synthetic compounds called naphthoquinones to see if they could fight a serious fungal infection called cryptococcosis. They found that one compound called 2-MNQ worked well against the fungus and was even more effective when combined with a standard antifungal drug (amphotericin B). The combination was strong enough to potentially allow lower doses of the existing drug, which could reduce side effects while improving treatment outcomes.

Research Keyword: therapeutic efficacy