Research Keyword: terpene synthase

Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites

Scientists have learned to use common baker’s yeast (S. cerevisiae) as a biological factory to produce valuable medicines and compounds that naturally come from fungi and mushrooms. By transferring the genetic instructions for making these compounds into yeast cells and improving them with genetic engineering, researchers can now produce therapeutically important substances like cancer-fighting drugs and antibiotics in large quantities. This approach is more practical and cost-effective than trying to extract these rare compounds directly from their native fungal sources or using other production methods.

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Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene

Scientists discovered that a special enzyme from a mushroom called Cyclocybe aegerita can make two different types of aromatic compounds instead of just one. By growing this enzyme in a different mushroom species that provides better raw materials, researchers identified a completely new compound called cyclocybene. This finding shows that using fungi as hosts for producing useful natural chemicals can work better than traditional bacterial systems, potentially opening new paths for making medicines and fragrances.

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Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi

Termite colonies farm a fungus called Termitomyces for food in an ancient partnership. Scientists discovered that the mushrooms produced by this fungus release distinctive chemical signals, particularly a compound called drimenol. By isolating and synthesizing these compounds, researchers found they have antimicrobial properties and may play a role in communicating between termites and their fungal crop or protecting mushrooms from infection.

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