telomere-to-telomere assembly

Saprotrophic Arachnopeziza Species as New Resources to Study the Obligate Biotrophic Lifestyle of Powdery Mildew Fungi

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Scientists studied two species of fungi called Arachnopeziza that are closely related to powdery mildew fungi but can grow independently on simple lab media. By analyzing their complete genomes and developing techniques to genetically modify these fungi, researchers created a new tool for understanding how powdery mildew fungi became dependent on plants. This breakthrough allows scientists to study these harmful plant pathogens more effectively without having to work directly with the difficult-to-cultivate powdery mildew fungi.

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress

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Researchers successfully sequenced the complete genome of Cordyceps militaris CH1, a medicinal fungus used in traditional Chinese medicine. By exposing the fungus to light and analyzing gene expression and metabolite changes, they discovered that light stress activates key genes involved in producing cordycepin, the main active medicinal compound. This breakthrough provides a foundation for improving cordycepin production in artificial cultivation, making this valuable medicine more affordable and accessible.

Trichoderma tlahuicanensis sp. nov. (Hypocreaceae), a novel mycoparasite of Fusarium oxysporum and Phytophthora capsici isolated from a traditional Mexican milpa

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Scientists discovered and formally named a new fungal species called Trichoderma tlahuicanensis, found in traditional Mexican farming fields. This fungus naturally attacks harmful plant diseases like those caused by Fusarium and Phytophthora, making it valuable for protecting crops without synthetic chemicals. The researchers used advanced DNA sequencing to confirm it was indeed a new species, distinct from known Trichoderma relatives.

Gapless near Telomer-to-Telomer Assembly of Neurospora intermedia, Aspergillus oryzae, and Trichoderma asperellum from Nanopore Simplex Reads

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Researchers developed a new method to create complete, high-quality genetic maps of fungi using a single affordable sequencing technology from Oxford Nanopore. They created an automated computer program that processes the sequencing data without human intervention and successfully assembled complete genomes for three industrially important fungal species. This breakthrough could make it much easier and cheaper for scientists to study and use fungi for producing medicines, food ingredients, and other useful compounds.

Telomere-to-telomere genome assembly of matsutake (Tricholoma matsutake)

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Scientists have successfully sequenced the complete genome of matsutake mushrooms for the first time. Using advanced DNA sequencing technology, they created a map of all 13 matsutake chromosomes containing about 22,000 genes. This achievement provides crucial information to help understand, preserve, and possibly improve this highly valued but increasingly rare mushroom that has been prized in Japanese cuisine for over a thousand years.

Research Keyword: telomere-to-telomere assembly

Saprotrophic Arachnopeziza Species as New Resources to Study the Obligate Biotrophic Lifestyle of Powdery Mildew Fungi