Research Keyword: TCA cycle

Impact of energy metabolism pathways in promoting phytoremediation of cadmium contamination by Bacillus amyloliquefaciens Bam1

mycolabadmin

Researchers developed genetically modified bacteria (Bacillus amyloliquefaciens) that produce more energy to better survive in cadmium-contaminated soil. These enhanced bacteria can then help tomato plants absorb and remove cadmium pollution from the soil more effectively. The best-performing modified strain increased cadmium accumulation in tomatoes by nearly 1.9 times compared to the original bacteria, offering a promising biological solution for cleaning contaminated agricultural soils.

Read More »

The very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Phs1 regulates ATP levels and virulence in Cryptococcus neoformans

mycolabadmin

Researchers found that a protein called Phs1, which helps Cryptococcus neoformans (a dangerous fungus) produce essential fatty acids, is important for the fungus to cause disease. When this protein was removed, the fungus produced less melanin (a pigment), couldn’t grow well at body temperature, and had a weaker cell wall. Most importantly, the fungus produced less energy (ATP) and was much less deadly in infected mice, suggesting that blocking Phs1 could potentially be a new way to treat cryptococcal infections.

Read More »

Antifungal Activity of Sesamol on Pestalotiopsis neglecta: Interfering with Cell Membrane and Energy Metabolism

mycolabadmin

Researchers found that sesamol, a natural compound found in sesame oil, effectively kills a harmful fungus that damages pine trees and other plants. The study showed that sesamol damages the fungus’s cell membranes and disrupts its energy production, ultimately killing it. These findings suggest sesamol could be developed as a natural alternative to chemical fungicides for protecting crops and forests from disease.

Read More »

Oxaloacetate anaplerosis differently contributes to pathogenicity in plant pathogenic fungi Fusarium graminearum and F. oxysporum

mycolabadmin

Two important crop-destroying fungi, Fusarium graminearum and F. oxysporum, rely differently on a metabolic enzyme called pyruvate carboxylase to cause disease. Researchers found that removing this enzyme completely eliminates the ability of F. oxysporum to infect tomato plants by blocking its capacity to penetrate roots and break down plant cell walls. However, the same enzyme deletion has minimal effect on F. graminearum’s ability to infect wheat, suggesting these fungi have evolved different metabolic strategies for attacking their hosts.

Read More »

Growth Phase-Dependent Changes in the Carbohydrate Metabolism of Penicillium Strains from Diverse Temperature Classes in Response to Cold Stress

mycolabadmin

This study examined how three types of fungus respond to cold temperatures by measuring changes in their metabolic enzymes. Researchers exposed young and old fungal cells to cold stress and found that cold temperatures increased enzyme activity in both energy production pathways. Interestingly, the Antarctic psychrotolerant fungus adapted better to cold than the mesophilic fungi, showing that cold-adapted organisms have superior strategies for surviving freezing conditions.

Read More »

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

mycolabadmin

This study examined how two types of honey mushrooms (Armillaria) fight each other when grown together. Researchers found specific chemical markers and metabolic pathways that are activated during this competition. The study identified 156 new compounds produced during co-culture, including 32 with potential antifungal properties. These findings could help understand how mushrooms naturally combat fungal pathogens.

Read More »
Scroll to Top