Research Keyword: synergy

Medicinal Mushrooms as Multicomponent Mixtures—Demonstrated with the Example of Lentinula edodes

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Shiitake mushrooms are more than just tasty food—they contain numerous compounds that work together to improve health. Unlike single isolated drugs, whole mushroom preparations offer multiple benefits including boosting immunity, protecting the heart, and potentially supporting cancer treatment. These mushrooms have been used safely in Asian medicine for over 2000 years and are becoming recognized worldwide for their health-promoting properties.

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Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates

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Scientists tested combinations of common antifungal medications with special inhibitor drugs that target fungal stress-response systems. When combined, these drugs worked better together against dangerous mold infections like Aspergillus and Rhizopus, especially those that are resistant to standard treatments. The combinations rarely caused harmful interactions and often enhanced the antifungal effects, suggesting this approach could improve treatment of serious mold infections.

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Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Researchers tested five compounds called naphthoquinones for their ability to fight a dangerous fungal infection called cryptococcosis. They found that one compound called 2-MNQ works especially well when combined with the standard antifungal drug amphotericin B, making the treatment more effective. This discovery could lead to better treatments for people with weakened immune systems who are vulnerable to this infection.

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