Research Keyword: synergistic effects

Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action

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Ganoderma is a medicinal mushroom that has been used in traditional medicine for thousands of years and shows promise as a natural antibiotic. The mushroom contains special compounds like polysaccharides and triterpenoids that can kill harmful bacteria and fungi by damaging their cell walls and boosting your immune system. Recent research shows it works against common infections like those caused by staph bacteria and E. coli, and may even help fight antibiotic-resistant germs.

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Drug repurposing to fight resistant fungal species: Recent developments as novel therapeutic strategies

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This editorial highlights the growing problem of fungal infections that resist current treatments, causing millions of deaths worldwide each year. Researchers are finding new ways to fight these resistant infections by repurposing existing drugs in new combinations and discovering novel compounds from natural sources. The collection of studies presented shows promising results using combinations like minocycline with antifungal drugs, natural compounds like baicalin, and AI technology to predict resistance patterns. These innovative approaches offer hope for better treatment options for patients suffering from serious fungal infections.

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Synergistic effects of Cyp51 isozyme-specific azole antifungal agents on fungi with multiple cyp51 isozyme genes

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This study found that different azole antifungal drugs work better against different versions of an enzyme (Cyp51) that fungi need to survive. By combining two azole drugs that each target different enzyme versions, researchers achieved stronger antifungal effects than either drug alone. This discovery suggests a new strategy for treating stubborn fungal infections by carefully selecting drug combinations based on which enzyme versions the fungus possesses.

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Synergistic Effects of Cold Atmospheric Multiple Plasma Jet and Amphotericin B on Leishmania major: An In-Vitro Study

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Researchers tested a new cold plasma technology combined with an existing anti-parasite drug (amphotericin B) against Leishmania parasites that cause skin infections. The cold plasma, which contains reactive chemicals, killed the parasites by triggering their programmed cell death (apoptosis) while causing minimal harm to human immune cells. When combined with the medication, the treatment was even more effective, potentially allowing lower drug doses with fewer side effects.

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