Research Keyword: structure elucidation

Hericioic Acids A–G and Hericiofuranoic Acid; Neurotrophic Agents from Cultures of the European Mushroom Hericium flagellum

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Researchers isolated eight new bioactive compounds from a rare European mushroom species called Hericium flagellum. These compounds showed promising ability to stimulate nerve cell growth and could potentially help treat neurodegenerative diseases like Alzheimer’s and Parkinson’s. The study demonstrates that mushroom-derived natural products may offer new therapeutic approaches for conditions affecting millions of elderly people worldwide.

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Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound

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Scientists discovered that when a dangerous fungus called Aspergillus terreus is grown together with immune cells, it produces a special compound called butyrolactone Ia that helps it hide from the body’s defense system. This compound works by reducing inflammatory signals that immune cells use to fight the fungus. The research shows that direct contact between the fungus and immune cells is needed to trigger this protective compound production, suggesting the fungus responds directly to the threat of immune attack.

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Antifungal effects of metabolites from Arthrinium sp. 2–65 and identification of main active ingredients

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Scientists discovered that a fungus called Arthrinium sp. 2–65, found living inside a wild plant called Thymus mongolicus, produces two special compounds that can kill the fungus responsible for grey mould disease. Grey mould is a major problem for farmers worldwide, damaging crops like tomatoes, grapes, and strawberries. These newly identified compounds were tested and showed excellent effectiveness against the disease, offering a promising natural alternative to chemical pesticides that have become less effective due to resistance and environmental concerns.

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Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol

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Researchers isolated new compounds from Lion’s mane mushroom (Hericium erinaceus) that can inhibit xanthine oxidase, an enzyme linked to breast cancer development. One compound called hericerin showed strong activity against a specific type of breast cancer cell (T47D cells) while being less harmful to normal cells. The study also corrected a misidentification from previous research, confirming that a compound previously thought to have a different structure was actually adenosine. These findings suggest Lion’s mane could be developed into a natural anti-cancer treatment.

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First Chemical Investigation of Korean Wild Mushroom, Amanita hemibapha subsp. javanica and the Identification of Anti-Helicobacter pylori Compounds

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Researchers studied a Korean edible mushroom called Amanita hemibapha subsp. javanica and found it contains compounds that can kill the bacteria Helicobacter pylori, which causes stomach ulcers and gastric cancer. One compound in particular showed strong antibacterial activity, performing even better than some known antibiotics. These findings suggest this mushroom could be a natural source for developing new medicines to treat H. pylori infections and fight antibiotic-resistant strains.

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