structure-activity relationship – Page 3

Biological and Cheminformatics Studies of Newly Designed Triazole Based Derivatives as Potent Inhibitors against Mushroom Tyrosinase

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Researchers developed new chemical compounds based on triazole structures to inhibit tyrosinase, an enzyme that produces melanin in skin. One compound (9h) proved particularly effective at blocking this enzyme, working 170 times better than the standard drug kojic acid. Computer modeling showed how this compound fits into the enzyme’s active site. These findings could lead to safer and more effective treatments for skin discoloration disorders like melasma and age spots.

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

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Scientists developed new chemical compounds that can block tyrosinase, an enzyme that produces skin pigment (melanin). These new compounds, called DHIT derivatives, work much better than existing skin lightening agents like kojic acid and appear to be safer. The best compound tested was 100 times more effective at stopping melanin production than kojic acid in laboratory tests and showed no toxicity to cells.

Research Keyword: structure-activity relationship

Biological and Cheminformatics Studies of Newly Designed Triazole Based Derivatives as Potent Inhibitors against Mushroom Tyrosinase

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies