structure-activity relationship

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications

mycolabadmin

Researchers studied a medicinal mushroom called Ganoderma lucidum to identify compounds that could fight cancer. They found nine rare compounds called depsidones that showed promise against different types of cancer cells, including liver, colon, breast, and lung cancer. The compounds were shown to work by binding to cancer-related proteins, suggesting they could be developed into new cancer treatments.

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

mycolabadmin

Scientists are searching for new treatments for COVID-19 by studying indole-containing compounds, which are found in many plants and can be made in laboratories. Some approved drugs with indole structures, like the antiviral drug Arbidol, have been repurposed to fight COVID-19. Researchers are also designing new indole compounds and using computer simulations to predict which ones might work best against the virus’s key proteins.

Structural Elucidation, Modification, and Structure-Activity Relationship of Polysaccharides in Chinese Herbs: A Review

mycolabadmin

This comprehensive review explains how the structure of plant polysaccharides from Chinese herbs determines their healing properties. The authors discuss various laboratory methods to identify polysaccharide structures and explain how chemical modifications can enhance their beneficial effects like boosting immunity and fighting tumors. The review provides guidance for researchers developing new polysaccharide-based medicines and shows that finding the right molecular size and chemical composition is key to maximizing therapeutic benefits.

4-Hydroxy-N,N-diisopropyltryptammonium hydrofumarate: Crystal Structure of a Synthetic Psychedelic

mycolabadmin

Scientists have determined the three-dimensional crystal structure of 4-HO-DiPT, a synthetic compound related to psilocin found in magic mushrooms. This is the first crystal structure of this specific compound and provides important structural information for understanding how it works. A related version of this compound is currently being tested in clinical trials for treating postpartum depression and other mood disorders.

Obtaining and Studying the Properties of Composite Materials from ortho-, meta-, para-Carboxyphenylmaleimide and ABS

mycolabadmin

Researchers developed new plastic materials based on ABS that can resist bacterial and fungal growth, making them ideal for medical equipment and food packaging. By adding special chemical additives (carboxyphenylmaleimides) to the plastic, the materials became antibacterial while maintaining their useful properties like strength and heat resistance. The study tested three different versions of these additives and found that all performed well against dangerous bacteria like E. coli and Staphylococcus aureus, with the potential to reduce infection risks in hospitals and healthcare settings.

Insights into the Mechanisms and Functional Effects of Insoluble Dietary Fiber Modification: A Review

mycolabadmin

Insoluble dietary fiber is important for digestive health but its rigid structure limits its usefulness in processed foods and medicine. Scientists can modify this fiber using various techniques like heating, pressure, enzymes, and chemicals to make it more effective. When combined properly, these modification strategies can dramatically improve dietary fiber’s ability to lower cholesterol, control blood sugar, and promote beneficial gut bacteria, making it valuable for functional foods and health applications.

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

mycolabadmin

Mushrooms contain special compounds called polysaccharides that have powerful health benefits. Scientists have found these polysaccharides can help fight cancer, boost immunity, reduce inflammation, and manage diabetes. This review explains different ways to extract and purify these beneficial compounds from mushrooms and describes how they work in the body to provide these health benefits.

Editorial: Dietary polysaccharides and brain health

mycolabadmin

This editorial examines how eating foods rich in polysaccharides, such as grains, fruits, and mushrooms, may help protect brain health and cognitive function as we age. The research suggests these foods work through the gut microbiota, which communicates with the brain via the gut-brain axis. While single fiber sources show modest effects, combining different types of fermentable fibers may be more effective for improving memory and preventing age-related cognitive decline.

Potential Bioactivities, Chemical Composition, and Conformation Studies of Exopolysaccharide-Derived Aspergillus sp. Strain GAD7

mycolabadmin

Scientists discovered a marine fungus called Aspergillus sp. strain GAD7 that produces a special type of sugar-like substance with medicinal properties. This substance can help prevent blood clotting and fight harmful substances in the body that cause damage. The research shows this fungal product could potentially be used as a therapeutic treatment for conditions related to blood clotting and oxidative stress.

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis

mycolabadmin

Researchers developed new chemical compounds that can inhibit tyrosinase, an enzyme responsible for producing melanin (the pigment that colors skin). One compound, called 5c, proved exceptionally effective at blocking this enzyme—significantly more potent than existing skin-lightening agents. These acetophenone-based compounds could lead to improved cosmetic treatments for unwanted pigmentation like age spots and melasma, with better safety profiles than current options.

Research Keyword: structure-activity relationship