Research Keyword: structural connectome

Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

Researchers studied how DMT affects the brain’s ability to switch between different activity patterns. Using simultaneous brain imaging (fMRI) and electrical recordings (EEG), they found that DMT makes these transitions easier and less energy-intensive. The effects occurred primarily in brain regions with high levels of serotonin 2a receptors and were accompanied by increased complexity of brain signals and stronger subjective drug effects.

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N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

Researchers studied how DMT, a powerful psychedelic drug, changes brain activity patterns and how these changes relate to what people experience. Using advanced brain imaging and network analysis, they found that DMT shifts brain activity away from large-scale network patterns toward smaller, more diverse patterns. Importantly, these brain changes directly tracked with how intensely participants reported experiencing the drug’s effects moment-to-moment.

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