Research Keyword: structural biology

Genome Sequence, Comparative Genome Analysis, and Expression Profiling of the Chitinase GH18 Gene Family in Cordyceps javanica Bd01

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Scientists sequenced the complete genome of Cordyceps javanica, a fungus used to control pest insects. They discovered that this fungus has an expanded family of 27 chitinase genes (GH18), which are enzymes that help the fungus penetrate insect exoskeletons. These genes show strong evolutionary conservation and stability, making them valuable for developing more effective natural pesticides and understanding how fungal biocontrol agents work.

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Discovery of novel targets for important human and plant fungal pathogens via an automated computational pipeline HitList

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Scientists developed a computer program called HitList that searches through fungal genes to find new targets for antifungal medicines. The program identifies proteins that are unique to harmful fungi and missing from humans and plants, making them ideal drug targets. The study found several promising new protein targets that could lead to development of more effective antifungal drugs to treat both human fungal infections and crop diseases caused by fungi.

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