Research Keyword: stress granules

Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host

Researchers discovered that a virus infecting the dangerous fungus Aspergillus fumigatus actually helps the fungus survive and cause worse infections in humans. By removing the virus from fungal strains, scientists found that the fungus became weaker and less able to cause disease in mice. Importantly, treating infected mice with an antiviral drug (ribavirin) reduced the viral load and helped the mice survive, suggesting a new approach to treating serious fungal infections.

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Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host

A virus that infects the fungus Aspergillus fumigatus makes the fungus more dangerous by helping it survive stress and resist immune cell attack. When researchers removed the virus from the fungus, it became weaker and less harmful to infected mice. Treating infected mice with an antiviral drug called ribavirin reduced the virus, lowering fungal burden and improving survival, suggesting that targeting fungal viruses could be a new way to treat serious fungal infections.

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Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host

A virus that infects the fungus Aspergillus fumigatus (which causes serious lung infections in humans) actually makes the fungus more dangerous by improving its ability to survive stress and spread disease. Scientists found that removing this virus from the fungus made infections less severe in mice. They also discovered that antiviral drugs like ribavirin could potentially be used to weaken these virus-infected fungi and improve patient survival.

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