Research Keyword: strain degeneration

The phenomenon of strain degeneration in biotechnologically relevant fungi

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Fungi used in industries to produce antibiotics, enzymes, and other useful products sometimes mysteriously lose their ability to produce these substances effectively. This review explains why this happens through various mechanisms including genetic changes, chemical modifications of genes, and stress responses. The authors provide practical strategies to prevent this loss of productivity, such as careful strain selection, proper storage methods, and tailored bioprocess design to maintain stable production.

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Effects of mating-type ratio imbalance on the degeneration of Cordyceps militaris subculture and preventative measures

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Cordyceps militaris is a medicinal fungus used in traditional Chinese medicine that has healing properties but degenerates quickly when repeatedly cultured in laboratories. This research found that the loss of genetic mating-type information during subculturing is the main cause of this degeneration. By separately culturing different genetic types and mixing them before production, or by using stable single genetic-type strains, farmers can maintain consistent quality fruiting bodies for harvest and medicinal use.

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Revitalization of the Endophytic Fungus Acremonium sp. MEP2000 and Its Impact on the Growth and Accumulation of Bioactive Compounds in Inonotus obliquus

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Researchers successfully revived a beneficial fungus called Acremonium sp. MEP2000 that had lost its effectiveness through repeated cultivation by adding birch bark powder and medicinal mushroom powder to its growth medium. When used to treat the medicinal fungus Inonotus obliquus (chaga), this revitalized fungal culture dramatically improved the growth and production of healthy bioactive compounds like polysaccharides and triterpenoids. This breakthrough offers a practical solution for large-scale production of medicinal fungi with enhanced therapeutic potential for treating cancer, diabetes, and inflammatory conditions.

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Integrated Transcriptomics and Metabolomics Provide Insight into Degeneration-Related Molecular Mechanisms of Morchella importuna During Repeated Subculturing

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This study explains why morel mushroom strains weaken when repeatedly grown in laboratories. Researchers found that degenerated strains lose the ability to produce protective compounds called flavonoids, which act as natural antioxidants. By understanding these molecular changes, the researchers suggest that avoiding frequent subculturing and using preservation methods like low-temperature storage could help keep morel strains healthy and productive.

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