Research Keyword: squalene epoxidase

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

Researchers in Thailand identified five patients with a new type of fungal skin infection caused by Trichophyton indotineae, a species that resists the common antifungal drug terbinafine. These infections appeared as rashes on various parts of the body and required treatment with alternative medications like itraconazole. The findings represent the first confirmed cases in Thailand and suggest this resistant fungus may be spreading globally. The study also showed that a simple urease test could help doctors identify this resistant strain quickly without waiting for complex genetic testing.

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The Kelch Repeat Protein VdKeR1 Is Essential for Development, Ergosterol Metabolism, and Virulence in Verticillium dahliae

Verticillium dahliae is a serious fungal disease that kills many important crops like cotton and tomato by clogging their water-conducting vessels. Scientists discovered a protein called VdKeR1 that helps this fungus grow and cause disease by controlling how it makes ergosterol, a crucial component of fungal cell membranes. When researchers removed this protein, the fungus grew poorly, couldn’t form survival structures, and was much less dangerous to plants.

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The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum

Researchers discovered that a protein called TrPtk2 helps dermatophytes resist terbinafine, a common antifungal medicine. They found that blocking this protein makes the fungus more susceptible to terbinafine. Additionally, they discovered that omeprazole, a stomach medication approved for human use, can be combined with terbinafine to make it more effective against resistant fungal infections.

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