Research Keyword: SQLE gene

Emerging antifungal resistance in Trichophyton mentagrophytes: insights from susceptibility profiling and genetic mutation analysis

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This study examined how common skin fungal infections caused by Trichophyton species are becoming resistant to standard antifungal treatments. Researchers tested 131 fungal isolates from China and analyzed their resistance genes to understand why some strains no longer respond to terbinafine and other antifungal drugs. They found that certain genetic mutations, particularly in the SQLE gene, make these fungi resistant to treatment and that different species have different resistance patterns. These findings help doctors better choose treatments and guide the development of new antifungal medications.

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Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand have identified five patients with a difficult-to-treat fungal skin infection caused by Trichophyton indotineae, a type of dermatophyte that resists the commonly used antifungal drug terbinafine. This is the first time this resistant fungus has been detected in Thailand. The team developed a simple, inexpensive test using urease to help identify these resistant infections more easily. Patients responded well to the antifungal drug itraconazole after other treatments failed.

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Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy

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Researchers in Italy analyzed the genetic makeup of a fungus called Trichophyton mentagrophytes that causes skin infections and appears to spread between people through sexual contact. The fungal strain studied was susceptible to all tested antifungal medications and shared similarities with a strain previously found in Moldova. This study helps doctors understand how this emerging fungal infection spreads globally and whether it’s developing resistance to treatments.

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Computational analysis of missense mutations in squalene epoxidase associated with terbinafine resistance in clinically reported dermatophytes

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Certain fungal skin infections are becoming resistant to terbinafine, a common antifungal medication, due to genetic mutations in an enzyme called squalene epoxidase. Using computer models and analysis tools, researchers identified which mutations most strongly reduce the drug’s effectiveness and where the protein changes occur. Four specific mutations were found to prevent terbinafine from binding to its target, offering insights that could help develop better antifungal treatments.

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Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy

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Researchers in Italy studied a fungal strain that causes skin infections, particularly ringworm and related conditions. This strain is spreading globally and can potentially be transmitted through sexual contact. The study found that the Italian strain is closely related to another strain found in Moldova and is susceptible to currently used antifungal medications. Understanding this fungus at the genetic level helps doctors monitor its spread and identify if it develops resistance to treatments.

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