Research Keyword: sporotrichosis treatment

Targeted long-read sequencing analysis and antifungal susceptibility profiles of Sporothrix schenckii isolates from Thailand

Researchers in Thailand studied a fungal infection called sporotrichosis caused by Sporothrix schenckii, which infects both cats and humans. Using advanced DNA sequencing technology from Oxford Nanopore, they identified and classified 26 fungal samples and tested how well common antifungal medications worked against them. They found that calmodulin gene sequencing was better than the standard ITS test for identifying the fungus species, and that about one-third of the samples showed reduced sensitivity to the main treatment drug, itraconazole.

Read More »

Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

Scientists studied how the body’s immune system defends against Sporothrix brasiliensis, a dangerous fungus spreading through Latin America. They found that two immune receptors called dectin-1 and dectin-2 are crucial for fighting this infection by activating killer T cells and controlling regulatory T cells. Surprisingly, a cytokine called IL-17, commonly associated with fungal defense, actually helps maintain tissue integrity rather than directly killing the fungus.

Read More »
Scroll to Top