spindle assembly checkpoint

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

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This research reveals that disabling certain cell division checkpoint proteins in the fungus Aspergillus fumigatus creates populations resistant to triazole antifungal drugs. The resistant fungal cells appear to have abnormal amounts of genetic material, suggesting that loss of these checkpoint controls allows cells with extra chromosomes to survive drug exposure. This discovery provides new insight into how dangerous fungal infections can develop resistance to our most important antifungal treatments.

MoMad2 With a Conserved Function in the Spindle Assembly Checkpoint Is Required for Maintaining Appressorial Turgor Pressure and Pathogenicity of Rice Blast Fungus

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Rice blast fungus causes significant crop damage worldwide. This research reveals that a protein called MoMad2 helps the fungus control its cell division timing and maintains pressure in specialized infection structures called appressoria, which are needed to penetrate rice leaves. When scientists removed the MoMad2 gene, the fungus became less effective at infecting rice plants, suggesting this protein could be a target for developing new disease control strategies.

Research Keyword: spindle assembly checkpoint

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

MoMad2 With a Conserved Function in the Spindle Assembly Checkpoint Is Required for Maintaining Appressorial Turgor Pressure and Pathogenicity of Rice Blast Fungus