Research Keyword: sphingolipid metabolism

The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection

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Fusarium verticillioides is a fungus that produces fumonisin B1, a poisonous compound that can contaminate corn and harm human and animal health. Remarkably, the fungus has evolved special protective mechanisms to survive its own poison. This study discovered that five genes in the fungus work together to shield it from fumonisin’s toxic effects by either breaking down the toxin or boosting the production of protective molecules called ceramides in cell membranes.

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Multi-omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance

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Researchers studied how the fungus Candida auris develops resistance to amphotericin B, an important antifungal drug. By evolving two laboratory strains of this fungus under drug pressure, they discovered two different ways the fungus can become resistant: one through stress management genes, the other through changes in its protective lipids. These findings help explain why some clinical infections with this dangerous fungus are so hard to treat.

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Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1

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Regular exercise, especially high-intensity training, can help improve depression symptoms in young people by changing how immune cells in the brain function. The study shows that exercise increases production of a specific enzyme (CerS1) in microglia, which are the brain’s immune cells. This enzyme helps balance certain fatty molecules that reduce brain inflammation, ultimately improving mood and reducing depression-like behaviors. The findings suggest exercise works similarly to antidepressant medications for adolescent depression.

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The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of Candida auris

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Candida auris is a dangerous fungal infection that resists many standard antifungal drugs. Researchers discovered that a protein called Gcn5 helps this fungus survive both drugs and the body’s immune system. By targeting Gcn5 with a new compound called CPTH2, scientists showed they could make the fungus more vulnerable to standard treatments like caspofungin, suggesting a promising new approach to fighting these infections.

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