Research Keyword: sphingolipid biosynthesis

The serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions

Scientists have discovered a new type of fungicide called pyridazine carboxamides that effectively kill plant-damaging fungi by blocking a key enzyme involved in their cell membrane formation. These compounds work against many common crop diseases like gray mold and leaf spots, though they are less effective against certain wheat pathogens. The research validates this new approach as a promising tool for protecting crops and managing fungicide resistance while maintaining global food security.

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The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection

This research reveals how corn fungi protect themselves from their own toxic products by employing specialized defense enzymes. Scientists discovered that five genes work together in a protective cluster, with some enzymes strengthening the fungal cell’s natural defenses while others actively break down the toxin. This discovery helps explain how dangerous fungi survive and could lead to better strategies for preventing mycotoxin contamination in crops and developing disease-resistant plants.

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