spherule formation – mycolab.ai

Key Fungal Secreted Proteases in Coccidioidomycosis

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Researchers studied how a dangerous fungus called Coccidioides causes disease by examining special proteins called proteases that the fungus secretes. They found that blocking these proteases prevented the fungus from forming the spherule structures that allow it to spread inside infected people. This discovery could lead to new treatments for coccidioidomycosis, a serious infection that affects people in the Southwest United States.

Select and Resequence Methods Enable a Genome-Wide Association Study of the Dimorphic Human Fungal Pathogen Coccidioides posadasii

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Scientists developed a new method to understand how different strains of the fungus Coccidioides posadasii, which causes Valley Fever, respond to temperature changes. By mixing multiple fungal strains together and sequencing their DNA after growing them at different temperatures, they identified a gene that helps determine whether the fungus grows better in hot (body temperature) or cool (environmental) conditions. This discovery could help explain how this dangerous fungus adapts to human infection and may lead to better treatments for Valley Fever.

Research Keyword: spherule formation

Key Fungal Secreted Proteases in Coccidioidomycosis

Select and Resequence Methods Enable a Genome-Wide Association Study of the Dimorphic Human Fungal Pathogen Coccidioides posadasii