Research Keyword: SNP phylogeny

Candida albicans bloodstream infections are comprised of diverse populations of strains, including antifungal tolerant strains that emerge during treatment failure

Researchers found that Candida albicans bloodstream infections contain multiple different strains, not just one strain as previously thought. Some strains are more tolerant to antifungal medications like micafungin, and when treatment is started, the drug-tolerant strains can be eliminated while drug-sensitive strains increase in number. This discovery suggests that treatment failures may occur because pre-existing drug-resistant strains are selected for during treatment.

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