Skin whitening – mycolab.ai

Synthesis of silver nanoparticles using Eucommia ulmoides extract and their potential biological function in cosmetics

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Scientists created tiny silver particles using a Chinese medicinal plant extract and found they could help skin look lighter and younger. These particles work by reducing dark pigments and protecting skin from oxidative damage. The nanoparticles were safe at low doses and didn’t harm skin cells, making them promising for use in cosmetic products.

Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway

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Scientists extracted a compound called nomilin from yuzu seeds and tested whether it could lighten skin by reducing melanin production. They found that nomilin works by blocking an enzyme called tyrosinase that makes melanin, and it reduces the activity of cell signaling pathways involved in skin darkening. The study shows nomilin could be used as a natural skin-whitening ingredient in cosmetics without the side effects of synthetic alternatives.

Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo

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This research shows that betel leaves, a traditional herb used in Asian cultures, can lighten skin pigmentation through multiple mechanisms. The extract works by reducing tyrosinase enzyme activity, activating cellular cleanup processes called autophagy, and boosting the body’s natural antioxidant defenses. In both laboratory cells and living mice exposed to UV radiation, betel leaves extract effectively reduced unwanted skin darkening, suggesting it could be developed into safe natural skin-whitening products.

Anti-Melanogenic Activity of Calocedrus formosana Wood Essential Oil and Its Chemical Composition Analysis

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Researchers tested an essential oil from Taiwan’s precious Calocedrus formosana wood to see if it could lighten skin by blocking melanin production. The oil worked very well at stopping melanin synthesis in laboratory cells, with a compound called thymol being responsible for most of the lightening effect. This natural product could potentially be used in skin whitening cosmetics and offers a safer alternative to synthetic ingredients.

Kojic Acid Showed Consistent Inhibitory Activity on Tyrosinase from Mushroom and in Cultured B16F10 Cells Compared with Arbutins

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This study compared four skin-whitening compounds to find the best one for use as a testing standard in laboratories. Kojic acid was found to be the most reliable choice because it effectively blocks the enzyme tyrosinase, which produces skin pigment, without damaging cells. The researchers tested these compounds both in test tubes and in actual melanoma cells to understand how they work differently.

Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

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Researchers studied maca root, an Andes plant traditionally used for health benefits, by fermenting it with beneficial bacteria (Lactobacillus strains). They tested whether fermented maca could reduce skin inflammation and prevent excessive skin darkening. The fermented version worked significantly better than regular maca at both reducing inflammation markers and inhibiting melanin production in skin cells, suggesting it could be a valuable ingredient in cosmetic products designed to brighten skin and reduce irritation.

Aokap9 gene knockout contributes to kojic acid synthesis in Aspergillus oryzae

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Researchers discovered that removing the Aokap9 gene in the fungus Aspergillus oryzae doubles the production of kojic acid, a valuable chemical used in skin-whitening cosmetics and food preservation. By combining the Aokap9 gene removal with modifications to other genes (kojR and AozfA), they achieved even higher production levels. This research provides a practical pathway for creating high-yield strains that can produce kojic acid more efficiently for commercial applications.

Tyrosinase Inhibitors Derived from Chemical Constituents of Dianella ensifolia

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Researchers isolated four new plant compounds and 67 known compounds from Dianella ensifolia, a traditional Asian medicinal plant. Two of these compounds (11 and 14) were found to inhibit tyrosinase, the enzyme responsible for melanin production, making them approximately 13 times more effective than arbutin, a common cosmetic whitening ingredient. These findings suggest that D. ensifolia could be developed as a natural source of skin-whitening agents for treating age spots, freckles, and other pigmentation disorders.

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

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Scientists developed new chemical compounds that can block tyrosinase, an enzyme that produces skin pigment (melanin). These new compounds, called DHIT derivatives, work much better than existing skin lightening agents like kojic acid and appear to be safer. The best compound tested was 100 times more effective at stopping melanin production than kojic acid in laboratory tests and showed no toxicity to cells.

Research Keyword: Skin whitening