Research Keyword: skin pigmentation

Synergistic impact of arbutin and kaempferol-7-O-α-l-rhamnopyranoside from Nephelium lappaceum L. on whitening efficacy and stability of cosmetic formulations

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This research demonstrates that a natural compound from rambutan seeds works synergistically with arbutin to create more effective skin whitening products. The combination is 35 times more potent than arbutin alone at preventing melanin production in skin cells. The resulting cosmetic formulation maintains its effectiveness and stability for approximately 5.2 months, offering a safer natural alternative to conventional skin lightening agents that can cause irritation.

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Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis

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Researchers developed new chemical compounds that can inhibit tyrosinase, an enzyme responsible for producing melanin (the pigment that colors skin). One compound, called 5c, proved exceptionally effective at blocking this enzyme—significantly more potent than existing skin-lightening agents. These acetophenone-based compounds could lead to improved cosmetic treatments for unwanted pigmentation like age spots and melasma, with better safety profiles than current options.

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Novel tyrosinase-inhibitory peptides derived from Locusta migratoria protein hydrolysates: Preparation, identification and molecular docking analysis

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Scientists have discovered that peptides from locusts can effectively inhibit tyrosinase, an enzyme responsible for skin pigmentation. These peptide extracts showed strong ability to prevent melanin production, comparable to existing skin-whitening agents but with much lower toxicity to normal cells. The research identified over 1100 different peptide sequences that could be useful in cosmetic and pharmaceutical products for treating age spots, freckles, and other pigmentation issues.

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Hirsutanone Isolated from the Bark of Alnus japonica Attenuates Melanogenesis via Dual Inhibition of Tyrosinase Activity and Expression of Melanogenic Proteins

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Researchers found that hirsutanone, a natural compound from East Asian alder bark, can reduce skin pigmentation by blocking melanin production through two mechanisms: directly inhibiting the tyrosinase enzyme and suppressing the cellular signals that trigger melanin-producing genes. In laboratory tests with both mouse and human skin cells, hirsutanone proved more effective than a related compound called oregonin at reducing melanin without harming the cells. This discovery suggests hirsutanone could potentially be developed into a treatment for pigmentation problems like age spots and melasma.

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Biological and Cheminformatics Studies of Newly Designed Triazole Based Derivatives as Potent Inhibitors against Mushroom Tyrosinase

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Researchers developed new chemical compounds based on triazole structures to inhibit tyrosinase, an enzyme that produces melanin in skin. One compound (9h) proved particularly effective at blocking this enzyme, working 170 times better than the standard drug kojic acid. Computer modeling showed how this compound fits into the enzyme’s active site. These findings could lead to safer and more effective treatments for skin discoloration disorders like melasma and age spots.

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