Research Keyword: single-cell transcriptomics

Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models

Scientists studied a gene called CAPZA2 that helps control how brain cells connect to each other. When this gene doesn’t work properly, mice had trouble learning, remembering things, and interacting socially, similar to intellectual disability in humans. The researchers found that the problem happens because the connections between brain cells become abnormal and don’t mature properly. This research helps explain why some people with mutations in this gene have developmental difficulties and could lead to new treatments.

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Unveiling SSR4: a promising biomarker in esophageal squamous cell carcinoma

Researchers discovered that a protein called SSR4 is overexpressed in esophageal cancer cells and is associated with poor patient outcomes. This protein appears to be involved in how cancer cells communicate with immune cells in the tumor environment. The findings suggest SSR4 could be used as a diagnostic marker and potential therapeutic target for treating esophageal cancer patients.

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