single-cell RNA sequencing

Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

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This research article, published as a correction, examines how chaga mushroom (Inonotus obliquus) may help treat kidney fibrosis in mice. Using advanced genetic sequencing technology that examines individual cells, scientists identified how chaga works by modulating communication between different immune and kidney cells. The findings suggest that chaga could be a promising natural treatment for progressive kidney disease.

Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

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Scientists studied individual nerve cells in fruit flies that control mating behaviors, comparing males and females at a critical developmental stage. Using advanced sequencing technology, they identified 113 distinct types of nerve cells with shared genes but sex-specific differences in expression. The findings reveal how the same basic neural circuits can be fine-tuned differently in males and females to produce their distinct reproductive behaviors.

Transcriptional programs mediating neuronal toxicity and altered glial–neuronal signaling in a Drosophila knock-in tauopathy model

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Researchers created a fruit fly model of frontotemporal dementia by editing the tau gene to match a human disease mutation. Using advanced genetic sequencing technology, they analyzed how this mutation affects brain cells, discovering that it disrupts communication between nerve cells and support cells called glia. The study reveals multiple pathways that could be targeted with future treatments to combat this devastating brain disease.

Research Keyword: single-cell RNA sequencing

Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

Transcriptional programs mediating neuronal toxicity and altered glial–neuronal signaling in a Drosophila knock-in tauopathy model