signaling pathways – mycolab.ai

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

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This comprehensive review examines how medicinal mushrooms contain natural compounds that can boost immune function, fight cancer cells, reduce inflammation, and protect nerve cells. Different mushroom species like reishi, shiitake, and maitake contain various active substances such as beta-glucans and triterpenes that work through multiple biological pathways. While laboratory and animal studies show promising results, more human clinical trials are needed to confirm effectiveness and establish safe dosing guidelines.

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice

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Researchers extracted and studied special compounds called polysaccharides from the spores of Cordyceps cicadae, a medicinal fungus used in traditional Chinese medicine. When tested in mice treated with a cancer drug that suppresses immunity, one of these purified compounds (CCSP-2) successfully restored immune function and reduced harmful oxidative stress. The compound works by boosting the activity of immune cells and protecting the body’s natural antioxidant defense systems, suggesting it could potentially help cancer patients manage chemotherapy side effects.

Prognostic model for gastric cancer patients with COVID-19 and network pharmacology study on treatment by lentinan

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This study investigated how lentinan, a compound from shiitake mushrooms, might help treat patients who have both gastric cancer and COVID-19. Researchers identified five genes that predict patient outcomes and found that lentinan may work by controlling immune cell activity and reducing inflammation. The study suggests lentinan could be a useful additional treatment for this challenging combination of diseases, though more research is needed.

Bioactive Peptides and Other Immunomodulators of Mushroom Origin

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Mushrooms contain special compounds called peptides and proteins that can boost your immune system and fight harmful bacteria. These mushroom-derived compounds show promise as natural alternatives to antibiotics, which are becoming less effective due to antibiotic resistance. Researchers are studying how these mushroom compounds could help treat difficult infections, wounds that won’t heal, and cancer, though more testing is needed before they can be used widely as medicines.

The Role of Wolfiporia cocos (F. A. Wolf) Ryvarden and Gilb. Polysaccharides in Regulating the Gut Microbiota and Its Health Benefits

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Wolfiporia cocos, a fungus used in traditional Chinese medicine for over 2000 years, contains polysaccharides that act as prebiotics to improve gut health. These polysaccharides promote the growth of beneficial bacteria while inhibiting harmful ones, increase production of healthy metabolites, and strengthen the intestinal barrier. By improving gut microbiota composition, these polysaccharides can help prevent and treat various diseases including obesity, diabetes, and inflammatory conditions.

Molecular mechanisms of metal toxicity and transcriptional/post-transcriptional regulation in plant model systems

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Plants face serious damage from heavy metals like cadmium, arsenic, and chromium in contaminated soils and water. Scientists are discovering how plants defend themselves through changes in gene expression, special proteins that trap metals, and modifications to their DNA that control stress response genes. Understanding these natural defense mechanisms could help us develop crops that survive in polluted environments and remove heavy metals from contaminated areas, making food safer and protecting human health.

Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

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Mushrooms contain special compounds that may help protect the brain from Alzheimer’s disease. Research shows that eating mushrooms regularly could reduce the risk of memory problems and cognitive decline in older adults. These compounds work by reducing brain inflammation, protecting nerve cells, and helping the brain clear out harmful proteins. While these findings are promising, more human studies are needed to confirm how effective mushrooms are as an Alzheimer’s treatment.

Microbial-mediated induced resistance: interactive effects for improving crop health

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This research explores how beneficial microbes like Trichoderma fungi and Bacillus bacteria can help plants naturally defend themselves against diseases. These microbes trigger the plant’s built-in immune system through chemical signals and molecular processes similar to how our immune system responds to threats. The approach offers an eco-friendly alternative to chemical pesticides for protecting crops, though effectiveness varies depending on environmental conditions.

Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms

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This comprehensive review examines how medicinal mushrooms can help treat cancer. Certain mushroom species and their compounds, particularly polysaccharides, can boost the immune system to fight cancer cells, reduce chemotherapy side effects, and overcome drug resistance. Multiple mushrooms are currently in clinical trials showing promise in improving cancer patient outcomes when used alongside conventional treatments.

Advances in the extraction, purification, structural characterization, and elucidation of the biological functions of polysaccharides from Hericium erinaceus

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Hericium erinaceus, commonly known as the monkey head mushroom, contains special molecules called polysaccharides that have numerous health benefits. Researchers have found that these polysaccharides can boost immunity, lower cholesterol and blood sugar, fight tumors, reduce inflammation, and promote healthy gut bacteria. Different extraction methods and purification processes can be used to obtain these beneficial compounds, making them useful for developing health supplements and medicines.

Research Keyword: signaling pathways