Research Keyword: signal transduction pathways

Sea buckthorn bioactive metabolites and their pharmacological potential in digestive diseases

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Sea buckthorn is an ancient medicinal plant containing hundreds of bioactive compounds that show promise in treating digestive diseases like stomach ulcers, colitis, and liver problems. This comprehensive review of 85 scientific studies found that sea buckthorn’s active ingredients work through multiple mechanisms including reducing inflammation, fighting harmful bacteria, protecting the intestinal lining, and balancing gut bacteria. The research suggests sea buckthorn could become a valuable natural supplement for digestive health, though more clinical trials are needed to confirm optimal doses and long-term effectiveness in humans.

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Psychedelics action and schizophrenia

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This review examines how psychedelic drugs like psilocybin and LSD affect the brain, particularly through serotonin receptors. While these compounds can produce psychosis-like symptoms similar to schizophrenia, they also promote brain plasticity and growth of neural connections. The article discusses whether psychedelics could potentially treat negative symptoms and cognitive problems in schizophrenia patients, despite their mind-altering properties, possibly through lower doses or non-hallucinogenic alternatives.

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Comparative phosphoproteome analysis to identify candidate phosphoproteins involved in blue light-induced brown film formation in Lentinula edodes

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Researchers studied how blue light triggers brown film formation on shiitake mushroom mycelia by analyzing protein modifications called phosphorylation. Using advanced mass spectrometry techniques, they identified thousands of phosphorylation changes in proteins when mushroom mycelia are exposed to blue light. The findings revealed that blue light activates several important processes including light sensing, pigment production, and cell wall degradation, providing insights into how mushrooms develop fruiting bodies in response to light signals.

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Phytochemicals as promising agents in Axl-targeted cancer treatment

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This review examines natural plant compounds that can block Axl, a protein that helps cancer cells survive and spread. Scientists found that compounds from common foods like apples, grapes, green tea, ginger, and chamomile can reduce Axl levels and kill cancer cells. These natural compounds work through different mechanisms and show promise for treating various cancers, including those resistant to standard chemotherapy drugs.

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Exploring the Critical Environmental Optima and Biotechnological Prospects of Fungal Fruiting Bodies

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This research identifies the ideal growing conditions for fungal fruiting bodies like mushrooms, showing that temperature around 25°C, high humidity, and proper light exposure are key factors. The study reveals that exceeding these optimal conditions typically harms development more than staying slightly below them. Scientists discovered that fungal fruiting bodies have important uses in medicine, food production, and environmental cleanup, and new genetic technologies like CRISPR could improve cultivation methods for better yields and quality.

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Phallus indusiatus Extracts Promoted MCF-7 Apoptosis Under TNFα-induced Tumor Microenvironment by Attenuating NF-kappaB and Akt Activation

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Bamboo mushroom extracts show promise in helping treat breast cancer by making cancer cells more sensitive to chemotherapy drugs. The mushroom reduces inflammation and blocks protective signals in cancer cells, making them more likely to die. This research suggests bamboo mushroom could be a helpful supplement for breast cancer patients, especially when used alongside standard cancer treatments.

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