Research Keyword: short-chain dehydrogenases/reductases

Boldenone and Testosterone Production from Phytosterol via One-Pot Cascade Biotransformations

Scientists developed an efficient biological process to produce testosterone and boldenone (important medical steroids) from plant sterols using two microorganisms working together. The fungus Curvularia converts the intermediate products produced by bacteria into the desired compounds. This green biotechnology approach avoids chemical synthesis and could provide a more sustainable way to produce these widely-used medicines for humans and animals.

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L-Rhamnose Dehydrogenase LraA of Aspergillus niger Shows High Substrate Specificity Matching Its Expression Profile

Scientists studied an enzyme called LraA found in a common fungus (Aspergillus niger) that breaks down L-rhamnose, a sugar found in plant cell walls. They discovered that this enzyme is extremely selective and only works on L-rhamnose, unlike most other similar enzymes that can process multiple types of sugars. This makes it very useful for biotechnology applications where researchers want to specifically convert L-rhamnose without affecting other pathways.

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