Research Keyword: serotonergic system

The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics

This paper explores how the thalamus, a key brain structure controlling attention and perception, malfunctions in Parkinson’s disease and similar neurological conditions, causing hallucinations and delusions. Interestingly, these symptoms resemble the altered mental states produced by psychedelic drugs like LSD and psilocybin. By studying both conditions together, researchers found that a common mechanism called thalamocortical dysrhythmia disrupts how the brain filters information and processes reality, offering new insights for treating psychotic symptoms.

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Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults – A Systematic Review

Psilocybin, a naturally occurring compound found in certain mushroom species, shows significant promise as a treatment for depression. Clinical studies reviewed in this research found that psilocybin-assisted therapy reduced depressive symptoms in every patient studied, with improvements lasting months after treatment. Unlike traditional antidepressants, psilocybin caused only mild temporary side effects and worked faster, suggesting it could become an important alternative treatment for depression.

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