Research Keyword: serotonergic pathways

Lysergic Acid Diethylamide (LSD) and the Heart: Exploring the Potential Impacts of LSD on Cardiovascular Function

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This review examines how LSD affects the heart and blood vessels. While some evidence suggests LSD might protect against heart disease by reducing inflammation and blood clots, acute use can dangerously raise heart rate and blood pressure, and cause blood vessel constriction. Regular low-dose use raises concerns about potential valve damage. More research is needed to understand the full cardiovascular safety of LSD before it can be considered for medical use.

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Are Side Effects Necessary for Antidepressive Treatment: The Psilocybin Experience

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Researchers are studying psilocybin (a compound from certain mushrooms) as a potential treatment for depression. However, there is debate about whether the hallucinogenic side effects are necessary for its therapeutic benefits. This paper argues that new research suggests the antidepressant effects work through specific brain pathways (serotonin, opioid, and glutamate systems) that don’t require hallucinations. The author suggests developing safer, non-hallucinogenic antidepressants that maintain the same therapeutic benefits.

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Psychedelic-assisted therapy for palliative care within a home treatment setting: A case report

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A 54-year-old man with terminal throat cancer received a single dose of LSD (100 μg) as part of psychedelic-assisted therapy delivered at his home. The treatment helped him experience relief from existential distress and feelings of peace. Six months later, he was in better psychological health, more motivated to pursue meaningful activities, and had discontinued pain medications while maintaining stability. This case demonstrates that psychedelic therapy can be safely administered at home for patients with life-threatening illnesses seeking existential relief.

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