Research Keyword: serotonergic mechanisms

Postpartum depression: A role for psychedelics?

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Postpartum depression affects many new mothers and involves feelings of disconnection from themselves and their babies. This review suggests that psilocybin, the active compound in psychedelic mushrooms, might help by promoting reconnection and acceptance. The authors examine safety data suggesting psilocybin could potentially be used safely in postpartum women if appropriate precautions are taken, such as temporarily stopping breastfeeding after treatment.

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Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder

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Researchers tested whether psilocybin mushrooms could help treat obsessive-compulsive disorder (OCD) using mice. They found that psilocybin reduced compulsive burying behavior in mice, similar to how approved OCD medications work. The study revealed that this anti-compulsive effect works through different brain mechanisms than previously thought, and that combining psilocybin with another drug called buspirone might block psychedelic effects while keeping therapeutic benefits.

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Psilocybin Does Not Induce Conditioned Place Preference, But Modifies Behavioral Patterns in Sprague-Dawley Rats

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Researchers tested whether psilocybin, a compound found in magic mushrooms, could be addictive by examining reward-seeking behavior in rats. The study found that psilocybin did not create rewarding effects that would typically lead to addiction, and only temporarily changed specific behaviors like head-twitching and grooming while the drug was active. These findings suggest that psilocybin has a low addiction potential and may be safe for therapeutic use in treating mental health conditions.

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Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

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This comprehensive analysis of clinical trials found that psilocybin, a compound found in certain mushrooms, shows promise as a treatment for depression compared to placebo. The treatment was particularly effective for patients with depression related to serious illness, those using self-reported symptom assessments, older adults, and those with prior experience with psychedelics. While side effects were minimal and temporary, researchers emphasize that more research is needed to fully understand how expectancy and individual factors influence treatment outcomes.

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