Research Keyword: serotonergic agonists

The Role of Psychedelics in the Treatment of Substance Use Disorders: An Overview of Systematic Reviews

This research review examines how psychedelic drugs like psilocybin and ketamine might help treat addiction. Studies show these substances could help people quit alcohol, drugs, and smoking by reducing cravings and promoting long-term abstinence. While results are promising, scientists caution that more rigorous research is needed before these treatments can be recommended for regular medical use, and they acknowledge real risks associated with these powerful drugs.

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Psilocin, LSD, mescaline, and DOB all induce broadband desynchronization of EEG and disconnection in rats with robust translational validity

Researchers tested how different psychedelic drugs affect brain electrical activity in rats using EEG recordings. They found that psilocin, LSD, mescaline, and DOB all produced similar patterns of decreased brain activity and reduced communication between brain regions. Importantly, these effects in rats closely matched what scientists observe in human brain studies, suggesting that rats can be useful for understanding how psychedelics work in the brain.

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