Research Keyword: serological testing

Splenic Infarct: A Rare Complication of Infectious Mononucleosis in a Monospot-Negative Patient

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A 21-year-old woman came to the hospital with fever, jaundice, and abdominal pain that persisted despite antibiotics. Although her monospot test for mononucleosis came back negative, blood tests for a virus called Epstein-Barr Virus (EBV) confirmed she had infectious mononucleosis. Imaging scans revealed multiple areas of dead tissue (infarcts) in her spleen caused by blocked blood vessels. She recovered well with rest and supportive care, highlighting how mononucleosis can sometimes cause serious complications even when the initial screening test is negative.

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Glycan microarray analysis of Candida-related antibodies in human and mice sera guides biomarker discovery and vaccine development

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Researchers developed a test using synthetic sugar molecules found on Candida yeast to detect antibodies in blood from infected patients and mice. They discovered that the immune system produces different antibodies at different stages of infection, starting with antibodies against certain sugars and later focusing on others. The study identified three specific sugar structures that could be used to create simple blood tests to diagnose Candida infections and potentially develop vaccines to prevent these serious fungal infections.

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