Research Keyword: serine protease

Purification and Biochemical Characterization of a Novel Fibrinolytic Enzyme from Culture Supernatant of Coprinus comatus

Scientists discovered and purified a powerful enzyme from the medicinal mushroom Coprinus comatus that can dissolve blood clots and prevent dangerous blood vessel blockages. This enzyme works in two ways: it can directly break down clots and also activate the body’s natural clot-dissolving systems. The enzyme is much smaller and safer than current blood-thinning medications, making it a promising natural alternative for treating heart disease and stroke.

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Proteases from Pleurotus spp.: Properties, Production and Biotechnological Applications

Oyster and king oyster mushrooms produce powerful enzymes called proteases that can break down proteins. These enzymes have multiple uses including fighting parasitic infections in animals and plants, making cheese, dissolving blood clots, and being used in detergents and cosmetics. The mushrooms can be grown on agricultural waste, making this a sustainable and cost-effective way to produce these valuable enzymes.

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Diverse origins of fibrinolytic enzymes: A comprehensive review

Blood clots can cause heart attacks and strokes, which are major causes of death worldwide. Currently used clot-dissolving drugs have significant drawbacks including short effectiveness periods and side effects. This review examines how fibrinolytic enzymes—naturally occurring proteins that dissolve blood clots—can be obtained from various sources, especially fermented foods like Japanese natto. These enzymes show promise as safer, cheaper alternatives that could be produced in large quantities for treating cardiovascular diseases.

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Purification and biochemical characterization of a novel thermostable protease from the oyster mushroom Pleurotus sajor-caju strain CTM10057 with industrial interest

Scientists discovered a special protein-cutting enzyme from oyster mushrooms that works exceptionally well at high temperatures and in harsh cleaning conditions. This enzyme, called SPPS, cuts through protein stains similar to how detergent enzymes work in laundry. The enzyme is more stable and efficient than commonly used commercial enzymes and can withstand organic solvents. This discovery makes it a promising candidate for improving detergent formulations and other industrial applications.

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