secondary metabolites – Page 10

Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis

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Researchers studied how adding selenium to Cordyceps militaris mushrooms affects their nutritional value and ability to prevent obesity. They found that selenium enrichment increased the mushroom’s carbohydrates and fiber content, and enhanced beneficial compounds like terpenoids and alkaloids. In mice fed a high-fat diet, both regular and selenium-enriched Cordyceps militaris reduced weight gain and improved metabolic health equally well. The study suggests these mushrooms work against obesity by using multiple active compounds that target different biological pathways simultaneously.

Advanced fermentation techniques enhance dioxolanone type biopesticide production from Phyllosticta capitalensis

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Researchers discovered that special fermentation techniques can significantly boost the production of natural pesticides from a beneficial fungus called Phyllosticta capitalensis. By using materials like glass wool during fermentation, they increased the production of specific bioactive compounds. The resulting extracts showed excellent effectiveness against garden pests like aphids and harmful nematodes, offering a natural alternative to synthetic pesticides for sustainable agriculture.

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

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Researchers studied a fungus called Aspergillus ficuum and found it contains compounds with potential medicinal benefits. The fungal extract showed strong antibacterial activity against disease-causing bacteria and reduced inflammation in mice. Additionally, the extract had antioxidant properties that help fight harmful free radicals, with no toxic effects observed, making it a promising candidate for developing new medications.

Comparative genome analysis of patulin-producing Penicillium paneum OM1 isolated from pears

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This research examined the genetic makeup of a mold called Penicillium paneum that contaminates pears and apples by producing a toxic substance called patulin. Scientists sequenced the entire genome and identified all the genes responsible for patulin production. They found that this mold has 33 different gene clusters for producing various toxic compounds, with the patulin-producing genes being highly similar to those in other related molds. This genetic knowledge could help develop better strategies to prevent patulin contamination in fruit crops.

Antifungal effect of soil Bacillus bacteria on pathogenic species of the fungal genera Aspergillus and Trichophyton

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Scientists found that certain bacteria naturally occurring in soil can effectively kill harmful fungi that cause infections in humans. By isolating and testing different Bacillus bacteria species, researchers discovered that some were even more effective at inhibiting fungal growth than commonly used antifungal medications. This finding suggests a promising natural alternative to combat fungal infections, especially as many fungi are becoming resistant to traditional antifungal drugs.

Antifungal Potential of Streptomyces-Derived Metabolites Against Fluconazole-Resistant Oral Candida albicans: In vitro Evaluation and Mechanistic Insights

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Researchers studied a type of soil bacteria called Streptomyces that produces natural compounds with strong antifungal properties. These compounds effectively killed drug-resistant Candida fungal infections that commonly affect cancer patients undergoing radiation therapy. The bacterial extract worked by damaging fungal cell membranes and blocking biofilm formation, which are protective structures the fungus uses to survive. While the results are promising for treating stubborn fungal infections, more research is needed to ensure safety for human patients.

Optimized production and characterization of red dye from Talaromyces purpureogenus PH7 for application as a textile dye

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Researchers optimized conditions to produce natural red dye from a fungus called Talaromyces purpureogenus, which could replace harmful synthetic dyes in the textile industry. The dye successfully colored cotton fabrics and resisted fading from washing and sunlight exposure. The fungus also produces beneficial compounds that could improve soil health, making this an environmentally friendly alternative to petroleum-based chemical dyes.

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides

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Researchers discovered five potent anti-cancer compounds from Arctic fungi called Acremonium strains. Using advanced chemical analysis techniques, they identified and tested these cyclic depsipeptides against various cancer cell types. The most active compound showed promising results against breast cancer and melanoma cells with extremely low concentrations needed for effect. These findings suggest Arctic microorganisms could be valuable sources for developing new cancer treatments.

Novel secondary metabolite from a new species of Hypoxylon saxatilis sp. nov. for suppressing bacterial wilt in tomato

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Scientists discovered a new type of fungus called Hypoxylon saxatilis that produces a natural compound called tetrahydrofuran. This compound effectively kills the bacteria that cause tomato plants to wilt and die. When used on tomato plants in the greenhouse, this fungal extract reduced disease severity by over 83%, offering a safer, environmentally friendly alternative to chemical pesticides for protecting crops.

The Biocontrol and Growth-Promoting Potential of Penicillium spp. and Trichoderma spp. in Sustainable Agriculture

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This review examines how two types of beneficial fungi, Penicillium and Trichoderma, can improve crop growth and protect plants from diseases without using chemical pesticides. These fungi work by colonizing plant roots, producing natural compounds that boost plant health, and fighting harmful pathogens. They are affordable, safe, and environmentally friendly alternatives for sustainable farming that can increase yields while reducing the need for synthetic fertilizers and fungicides.

Research Keyword: secondary metabolites