secondary metabolite

Photoregulation of the biosynthetic activity of fungus Inonotus obliquus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation

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Scientists studied how to enhance the medicinal properties of chaga mushroom using tiny metal particles and laser light. They found that adding silver, iron, or magnesium nanoparticles to growing mushroom cultures increased biomass production. When combined with laser treatment, these nanoparticles dramatically boosted the production of beneficial compounds like polysaccharides, flavonoids, and melanin pigments that have health benefits including antioxidant and immune-boosting properties.

Physiological Insights into Enhanced Epsilon-Poly-l-Lysine Production Induced by Extract Supplement from Heterogeneous Streptomyces Strain

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Researchers discovered that exposing bacteria that produce epsilon-poly-l-lysine (a natural antimicrobial compound) to extracts from another closely related bacterium dramatically increases production by 2.6-fold. Using advanced analysis techniques, they found that this boost occurs because the extract triggers the bacteria to activate defense mechanisms, rerouting its metabolism to produce more of this antimicrobial compound. This finding could significantly reduce the cost of producing this useful natural preservative for foods and medicines, making it more commercially viable.

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

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Scientists studied how different sugar sources (fructose versus sucrose) affect the production of cyclosporine A, an important drug used to prevent organ rejection after transplants. Using advanced protein analysis techniques, they identified which proteins were more active in each sugar environment and discovered that fructose promotes drug production while sucrose promotes fungal growth. This research could help pharmaceutical companies produce cyclosporine more efficiently by identifying key proteins to enhance.

Rediscovery of viomellein as an antibacterial compound and identification of its biosynthetic gene cluster in dermatophytes

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Researchers discovered that skin-infecting fungi called dermatophytes produce a red pigment called viomellein that kills bacteria. By studying the genes responsible for making viomellein, scientists found that this compound may help dermatophytes establish infections by eliminating competing bacteria on the skin. This discovery could explain how these fungi successfully colonize human skin and may lead to new treatment strategies for stubborn fungal infections.

Production of the light-activated elsinochrome phytotoxin in the soybean pathogen Coniothyrium glycines hints at virulence factor

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Researchers discovered that a fungus infecting soybean plants produces red toxins that become dangerous when exposed to light. These toxins generate reactive oxygen species that damage plant cells, causing leaf spots and disease. The study found that disease is worse under light conditions but can still occur in darkness, suggesting multiple attack mechanisms. Understanding this toxin production may help develop better disease management strategies for soybean crops, particularly in Africa where the disease is common.

Novel secondary metabolite from a new species of Hypoxylon saxatilis sp. nov. for suppressing bacterial wilt in tomato

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Researchers discovered a new fungus species (Hypoxylon saxatilis) living inside medicinal plants that produces a novel compound called tetrahydrofuran. This compound kills the bacterium that causes tomato wilt disease by damaging bacterial cell walls. In greenhouse tests, extract from this fungus reduced wilt disease severity by over 83%, suggesting it could be developed as an eco-friendly alternative to chemical pesticides for protecting tomato crops.

Research Keyword: secondary metabolite

Photoregulation of the biosynthetic activity of fungus Inonotus obliquus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation

Physiological Insights into Enhanced Epsilon-Poly-l-Lysine Production Induced by Extract Supplement from Heterogeneous Streptomyces Strain

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Rediscovery of viomellein as an antibacterial compound and identification of its biosynthetic gene cluster in dermatophytes

Production of the light-activated elsinochrome phytotoxin in the soybean pathogen Coniothyrium glycines hints at virulence factor

Novel secondary metabolite from a new species of Hypoxylon saxatilis sp. nov. for suppressing bacterial wilt in tomato