RNA-Seq – Page 5 – mycolab.ai

Transcriptomic Profiling of Thermotolerant Sarcomyxa edulis PQ650759 Reveals the Key Genes and Pathways During Fruiting Body Formation

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Researchers studied how a special strain of Sarcomyxa edulis (a tasty edible mushroom from Northeast China) develops fruiting bodies by analyzing which genes are turned on and off during this process. By comparing immature mycelium with developing fruiting bodies, they identified key genes responsible for cell division, DNA repair, and energy metabolism that control fruiting body formation. This knowledge can help mushroom farmers improve yield and quality through better understanding of how mushrooms grow. The findings provide a foundation for developing better cultivation techniques and selecting superior mushroom strains for commercial production.

Comparative transcriptome analysis reveals the genetic basis underlying the biosynthesis of polysaccharides in Hericium erinaceus

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Researchers studied six different strains of lion’s mane mushrooms to understand how they produce beneficial compounds called polysaccharides. Using advanced genetic analysis, they identified thirteen key genes responsible for making these health-promoting molecules. The study found that a strain called PZH-05 produced the most polysaccharides, and its genes were more active than in other strains. This research helps explain why lion’s mane mushrooms are effective for boosting immunity, fighting cancer, and managing blood sugar.

Integration of ATAC-Seq and RNA-Seq Identifies Key Genes in Light-Induced Primordia Formation of Sparassis latifolia

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Researchers studied how light triggers the formation of mushroom fruiting bodies in Sparassis latifolia using advanced molecular techniques. They identified 30 key genes that become more or less active during this light-induced transformation, particularly those involved in vitamin and amino acid metabolism. The genes identified are associated with pathways that help convert simple fungal threads into the complex mushroom structures we eat. These findings could help improve mushroom cultivation methods and deepen our understanding of how mushrooms develop.

Enhancement and Mechanism of Ergosterol Biosynthesis in Termite Ball Fungus Athelia termitophila by Methyl Jasmonate

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Scientists studied how to increase ergosterol production in termite ball fungus, a medicinal fungus used in traditional medicine. By adding methyl jasmonate, a natural signaling molecule, they more than doubled ergosterol content. Ergosterol is used to make vitamin D2 and certain medications for inflammation and cancer. The study identified which genes need to be activated for better ergosterol production, providing insights for creating more effective medical products from fungi.

The transcription factor RttA contributes to sterol regulation and azole resistance in Aspergillus fumigatus

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Researchers corrected the mislabeled rttA gene in the dangerous fungus Aspergillus fumigatus and discovered it acts as a master control switch for sterol production and antifungal drug resistance. When this gene is active, it helps fungi survive azole medications by boosting production of ergosterol, a critical component of fungal cell membranes. This discovery reveals how fungi develop resistance to our frontline antifungal treatments and suggests new ways to combat these life-threatening infections.

Transcriptome Analysis Reveals Critical Genes Involved in the Response of Stropharia rugosoannulata to High Temperature and Drought Stress

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This study examined how a type of edible mushroom called Stropharia rugosoannulata responds to high heat and dry conditions by analyzing which genes become active. Researchers found that under stress, the mushroom activates specific genes that help it survive, particularly through a cellular communication pathway called MAPK. They identified 15 key genes that could be useful for breeding mushroom varieties that better withstand harsh growing conditions, which could improve mushroom farming efficiency.

Volatile Metabolome and Transcriptomic Analysis of Kosakonia cowanii Ch1 During Competitive Interaction with Sclerotium rolfsii Reveals New Biocontrol Insights

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This research demonstrates how a beneficial bacterium called Kosakonia cowanii Ch1 can fight a harmful fungus that damages crops. The bacterium produces volatile chemicals that inhibit fungal growth and shows different gene activity depending on whether these chemicals are present. When the beneficial bacteria and fungus compete together with the volatiles present, the bacteria win by producing gas bubbles and effectively stopping the fungus. These findings suggest a natural alternative to chemical fungicides for protecting crops.

Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris

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Researchers identified 22 genes in the medicinal fungus Cordyceps militaris that control how genetic information is accessed through histone modifications. By studying how these genes respond to salt and amino acid treatments, they found that two specific genes (CmSET14 and CmSET16) are linked to cordycepin production, a compound with potential anti-cancer properties. When these genes were enhanced in the fungus, cordycepin production increased significantly, offering a new strategy to boost production of this valuable medicinal compound.

Volatile Metabolome and Transcriptomic Analysis of Kosakonia cowanii Ch1 During Competitive Interaction with Sclerotium rolfsii Reveals New Biocontrol Insights

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Researchers studied how a beneficial bacterium called K. cowanii fights against a harmful soil fungus (S. rolfsii) that damages crops like chili peppers. The bacterium produces special smelly compounds (VOCs) that kill the fungus. When these compounds are present, the bacterium activates specific genes that help it produce substances to protect itself and inhibit fungal growth. This research could help farmers use natural biocontrol instead of chemical fungicides.

New insights into the stress response mechanisms of stress-resistant Listeria monocytogenes via multi-omics and cell morphological changes

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Researchers studied how a dangerous food-poisoning bacterium called Listeria monocytogenes survives in harsh conditions like cold temperatures, acidic environments, and salty food products. Using advanced molecular analysis techniques, they identified specific genes and proteins that help the bacteria survive these stressful conditions. They also observed that the bacteria changed shape when exposed to stress, becoming elongated and bumpy. This research helps food safety experts better understand and combat this persistent food contaminant.

Research Keyword: RNA-Seq