RNA-binding proteins

Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development in Coprinopsis cinerea

mycolabadmin

Scientists studied a gene called ort2 in mushrooms that controls how fruiting bodies develop, especially the long structures called dark stipes that form in darkness. They found that when this gene is active, mushrooms make more of these elongated forms, while disabling it prevents dark stipe formation. This discovery could help improve mushroom cultivation for species where these elongated forms are commercially valuable.

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

mycolabadmin

ELAV/Hu proteins are molecular machines that control how cells read and use genetic instructions. Found mostly in the brain and nervous system, these proteins help manage which genes get turned on or off, which is crucial for proper brain development and function. When these proteins go wrong, they can contribute to serious diseases like Alzheimer’s, Parkinson’s, cancer, and autism, making them promising targets for new treatments.

Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition

mycolabadmin

Researchers discovered a special type of RNA called circDS-1 that helps a deadly fungus switch between two different forms depending on temperature. This fungus normally grows as a mold in soil but transforms into a yeast when it infects humans at body temperature. The circDS-1 RNA acts like a molecular switch that controls this transformation and helps the fungus cause infection. This discovery reveals that fungi may use hidden genetic elements beyond traditional genes to adapt to their environment.

A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control

mycolabadmin

Scientists discovered a critical protein called Puf4 in harmful water mold pathogens (oomycetes) that damage crops. When they removed this protein from the pathogens, the organisms grew poorly and couldn’t infect plants effectively. They also developed a new method to deliver therapeutic RNA directly through zoospores (swimming spores) that successfully reduced disease in infected plants, offering an eco-friendly alternative to traditional pesticides.

Research Keyword: RNA-binding proteins

Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development in Coprinopsis cinerea

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition

A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control