Research Keyword: ribosome biogenesis

Antifungal mechanism of ketone volatile organic compounds against Pseudogymnoascus destructans

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Researchers discovered that two ketone compounds, 2-undecanone and 2-nonanone, effectively kill Pseudogymnoascus destructans, the fungus that causes white-nose syndrome in bats. Using advanced genetic analysis, they found these ketones work by damaging the fungus’s cell structure, disrupting its energy production, and causing DNA damage. This research provides a foundation for developing new fumigant treatments to protect bat populations from this devastating fungal disease.

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A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control

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Scientists discovered a critical protein called Puf4 in harmful water mold pathogens (oomycetes) that damage crops. When they removed this protein from the pathogens, the organisms grew poorly and couldn’t infect plants effectively. They also developed a new method to deliver therapeutic RNA directly through zoospores (swimming spores) that successfully reduced disease in infected plants, offering an eco-friendly alternative to traditional pesticides.

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