Research Keyword: response surface methodology

Engineered biosynthesis and characterization of disaccharide-pimaricin

Scientists successfully created a genetically engineered bacterium that produces a safer version of an antifungal drug called pimaricin. The new version, called disaccharide-pimaricin, dissolves much better in water and causes significantly less damage to human blood cells, making it a much safer option for treating fungal infections. Although it’s slightly less effective at killing fungi, the improvement in safety and solubility makes it a promising candidate for treating eye infections and other fungal diseases.

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Modelling the Combined Effects of Oxalic Acid, Water Activity, and pH on the Growth and Mycotoxin Production of Aspergillus spp. in a Dried Fig System

This research develops computer models to predict when dangerous molds grow on dried figs and produce toxins. Scientists tested how wet the figs are, their acidity, and a natural plant compound called oxalic acid affect the growth of two common toxic molds. The study found that drier figs are much safer from toxin production, and while oxalic acid alone isn’t a strong mold-fighter, it can help when combined with other conditions. These models can help the fig industry prevent contamination and keep dried figs safe for consumers.

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Extraction, purification, and identification of total saponins from hazel mushroom and its application evaluation

Researchers developed an efficient method to extract beneficial compounds called saponins from hazel mushrooms using microwaves. They identified 22 different chemical compounds in these extracts and tested their effects on cancer cells and oxidative stress. The saponin extracts significantly inhibited the growth of lung cancer and bone cancer cells and demonstrated antioxidant properties, suggesting hazel mushrooms could be developed into functional foods or medicines.

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