response surface methodology – Page 3

Physicochemical, microbiological, and microstructural changes in germinated wheat grain

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When wheat grains are exposed to moisture and warm conditions, they begin to sprout, which damages their quality and usefulness. This research studied how different moisture, temperature, and time conditions affect sprouted wheat grain. Scientists found that sprouting significantly changes the grain’s structure, reducing its starch content and increasing microbial contamination. The findings suggest that sprouted wheat can be processed into useful products if grown under carefully controlled conditions.

Modelling the Combined Effects of Oxalic Acid, Water Activity, and pH on the Growth and Mycotoxin Production of Aspergillus spp. in a Dried Fig System

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Dried figs can become contaminated with harmful fungi that produce dangerous toxins during the drying process. Researchers used mathematical modeling to understand how water content, acidity, and oxalic acid treatment affect fungal growth and toxin production in figs. They found that reducing water content is the most effective way to prevent dangerous toxin buildup. These models help the fig industry identify and avoid conditions that promote contamination, ultimately making dried figs safer for consumers.

Optimization of triterpenoids biosynthesis in Athelia termitophila as a source of natural products

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Researchers optimized growing conditions for a fungus found in termite nests to dramatically increase production of triterpenoids, naturally-occurring compounds with potent health benefits. Using statistical methods to test different nutrients and conditions, they nearly doubled triterpenoid production and mycelial biomass. These findings could make triterpenoid-based medicines and supplements more affordable and widely available by improving natural production methods.

Identification of antagonistic activity against Fusarium, and liquid fermentation of biocontrol Bacillus isolated from wolfberry (Lycium barbarum) rhizosphere soil

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Researchers isolated a beneficial bacterium called Bacillus subtilis from wolfberry soil that fights a fungal disease called Fusarium root rot. Through careful optimization of growing conditions, they increased the bacteria’s effectiveness at killing the harmful fungus by about 15%. When added to wolfberry seedlings, this bacterium not only prevented fungal disease but also boosted plant growth significantly.

Artificial intelligence-assisted optimization of extraction enhances the biological activity of Phylloporia ribis

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Scientists optimized how to extract beneficial compounds from Phylloporia ribis mushrooms using artificial intelligence, finding that an AI-assisted method produced extracts with stronger antioxidant power and cancer-fighting properties than traditional statistical approaches. The optimized extracts showed promise in fighting free radicals, potentially supporting brain health against Alzheimer’s disease, and slowing cancer cell growth. This research demonstrates how combining mushroom extraction with modern AI technology could lead to more effective natural medicines.

Optimisation and Characterisation of Novel Angiotensin-Converting Enzyme Inhibitory Peptides Prepared by Double Enzymatic Hydrolysis from Agaricus bisporus Scraps

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Scientists discovered three new peptides in common button mushroom scraps that can lower blood pressure by blocking an enzyme called ACE. Using special enzymes to break down mushroom proteins and then purifying the result, they created peptides with strong blood pressure-lowering activity that survive stomach digestion well. This finding turns mushroom waste into a valuable source for making natural blood pressure medications that are safer than synthetic alternatives.

Optimization of Ultrasonic Extraction to Obtain Erinacine A and Polyphenols with Antioxidant Activity from the Fungal Biomass of Hericium erinaceus

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Researchers developed an efficient ultrasonic extraction method to obtain beneficial compounds from the lion’s mane mushroom (Hericium erinaceus), particularly a substance called erinacine A and antioxidants. The optimized process uses 80% ethanol and takes 45 minutes, producing extracts rich in antioxidants that can protect cells from damage. These extracts showed promise in protecting brain cells and could potentially help prevent or treat neurodegenerative diseases like Alzheimer’s disease.

Engineered biosynthesis and characterization of disaccharide-pimaricin

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Scientists engineered a bacterium to produce a modified antibiotic called disaccharide-pimaricin that fights fungal infections with much better safety. This new compound dissolves better in water (107 times more soluble) and is much less toxic to human blood cells (12.6 times safer) compared to regular pimaricin, while still maintaining antifungal effectiveness. Through optimized fermentation processes, they achieved high production yields of 138 mg/L, making this a promising candidate for safer antifungal treatments.

Statistical methodologies for enhancing lipase production from Aspergillus Niger and using biologically treated cottonseed waste in animal nutrition

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This study shows how scientists can grow an enzyme called lipase on cottonseed waste using a fungus called Aspergillus niger. The leftover treated material becomes excellent animal feed with high protein and important amino acids. This approach solves two problems at once: producing valuable enzymes for industry while creating nutritious feed for livestock from agricultural waste.

Citric Acid Induces the Increase in Lenthionine Content in Shiitake Mushroom, Lentinula edodes

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Shiitake mushrooms are prized for their unique flavor, which comes from a compound called lenthionine. This study found that treating shiitake mushrooms with citric acid (a common ingredient in food) can significantly increase the amount of lenthionine produced. The research identified the specific genes and enzymes responsible for this effect and determined the best conditions for the treatment, which could help mushroom producers create higher-quality, better-tasting products at lower cost.

Research Keyword: response surface methodology