regulatory T cells – mycolab.ai

From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance

mycolabadmin

This comprehensive review explains how prebiotics—special dietary fibers that feed beneficial gut bacteria—help maintain a healthy digestive system and strong immune response. By nourishing good bacteria and directly strengthening the intestinal barrier, prebiotics can reduce harmful inflammation and potentially lower cancer risk. Different types of prebiotics like inulin and resistant starch work through both bacterial fermentation and direct immune cell interaction, making them promising tools for preventing various diseases.

Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy

mycolabadmin

This review examines how traditional Chinese medicine ingredients can boost the body’s natural ability to fight cancer when combined with tiny nanoparticles that deliver drugs more effectively. The nanoparticles help TCM compounds work better by improving how they dissolve, how long they stay in the body, and where they target. By activating immune cells like natural killer cells and dendritic cells while reducing immune-suppressing cells, this combination approach offers a promising new strategy for cancer treatment with fewer side effects.

Gut Microbiome and Immune System Crosstalk in Chronic Inflammatory Diseases: A Narrative Review of Mechanisms and Therapeutic Opportunities

mycolabadmin

Your gut contains trillions of bacteria that play a crucial role in keeping your immune system balanced. When this bacterial community becomes imbalanced (dysbiosis), it can lead to chronic inflammatory diseases like arthritis, inflammatory bowel disease, psoriasis, and lupus. Recent research shows that restoring a healthy gut microbiota through diet, probiotics, prebiotics, or fecal transplants may help treat these conditions by reducing inflammation and strengthening the gut barrier.

Fungal Microbiome Diversity in Urban Forest Decreases Asthma and Allergic Inflammation

mycolabadmin

This study found that living near urban forests with diverse fungal species may protect against asthma. Researchers collected fungi from air samples in Seoul and found that areas with more forests had fewer asthma cases. Laboratory tests showed that fungi from forests were better at reducing allergic inflammation than fungi from city centers. The diversity of fungal species, rather than specific types, appeared to provide protective benefits.

Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

mycolabadmin

Scientists studied how the immune system fights a dangerous fungal infection called sporotrichosis caused by Sporothrix brasiliensis. They found that two immune receptors called dectin-1 and dectin-2 are crucial for fighting this infection by activating specific killer T cells and preventing immune suppression. Unlike what was previously thought, these receptors don’t work mainly by triggering inflammation, but rather by fine-tuning the balance of different immune cell types. This discovery could help develop new treatments for this emerging fungal disease.

Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

mycolabadmin

Researchers studied how the body fights a dangerous fungus called Sporothrix brasiliensis that causes sporotrichosis. They found that two immune receptors called dectin-1 and dectin-2 are crucial for protecting against this infection in mice. Surprisingly, these receptors work by activating killer immune cells and controlling regulatory immune cells, rather than through the typical immune response pathway scientists expected.

Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

mycolabadmin

Scientists studied how the body’s immune system defends against Sporothrix brasiliensis, a dangerous fungus spreading through Latin America. They found that two immune receptors called dectin-1 and dectin-2 are crucial for fighting this infection by activating killer T cells and controlling regulatory T cells. Surprisingly, a cytokine called IL-17, commonly associated with fungal defense, actually helps maintain tissue integrity rather than directly killing the fungus.

Probiotics in inflammatory bowel diseases: emphasis on mechanisms and clinical application

mycolabadmin

This review explores how probiotics (beneficial live bacteria) can help treat inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Probiotics work by restoring healthy bacteria balance in the gut, strengthening the intestinal barrier, and calming the immune system’s inflammatory response. While more research is needed, particularly for Crohn’s disease, probiotics show promise as a safe, long-term treatment option that can complement standard medications and improve patients’ quality of life.

Divergent Immunomodulatory Roles of Fungal DNA in Shaping Treg and Inflammatory Responses

mycolabadmin

Different types of fungal DNA trigger different immune responses in the body. DNA from the common yeast Candida albicans promotes immune tolerance and protects T cells, similar to beneficial bacterial DNA. In contrast, DNA from the pathogenic fungus Cryptococcus neoformans triggers strong inflammatory immune responses. This discovery reveals that fungal DNA itself, not just fungal cell wall components, plays an important role in determining whether fungi are treated as friendly commensals or dangerous pathogens by the immune system.

Research Keyword: regulatory T cells