Research Keyword: Reactive oxygen species

Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans

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This research shows that an extract from the Phoenix oyster mushroom (Pleurotus pulmonarius) can boost the body’s immune cells to fight dangerous fungal infections caused by Cryptococcus neoformans. When immune cells are pre-exposed to this mushroom extract and then encounter the fungus, they become more effective at killing it through increased production of immune-signaling molecules and reactive oxygen species. This natural supplement approach offers a promising alternative to traditional antifungal drugs, which often have significant side effects and can lead to drug resistance.

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Antifungal Activity of Genistein Against Phytopathogenic Fungi Valsa mali Through ROS-Mediated Lipid Peroxidation

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Scientists discovered that genistein, a natural compound found in soybeans and other legumes, can effectively kill the fungus that causes apple tree canker disease. The compound works by creating harmful reactive oxygen species that damage the fungus’s cell membranes and disrupt its normal cellular functions. This research suggests genistein could be developed as a safe, natural alternative to chemical fungicides for protecting apple crops.

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Symbiotic Fungus Serendipita indica as a Natural Bioenhancer Against Cadmium Toxicity in Chinese Cabbage

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This research shows that a beneficial fungus called Serendipita indica can help Chinese cabbage plants survive cadmium contamination. When the fungus colonizes plant roots, it triggers the plant’s natural defense systems to produce protective compounds and reduce heavy metal damage. This finding offers farmers an eco-friendly, biological solution for growing vegetables safely in contaminated soils without harmful chemical treatments.

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Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Scientists tested five synthetic compounds called naphthoquinones to see if they could fight a serious fungal infection called cryptococcosis. They found that one compound called 2-MNQ worked well against the fungus and was even more effective when combined with a standard antifungal drug (amphotericin B). The combination was strong enough to potentially allow lower doses of the existing drug, which could reduce side effects while improving treatment outcomes.

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